Searchable abstracts of presentations at key conferences in endocrinology

ea0070ep451 | Thyroid | ECE2020

When levothyroxine is not enough- combination therapy with liothyronine

Veríssimo David , Reis de Almeida Luís , Monteiro Manuel , Dias Luís

Introduction: The treatment of central hypothyroidism with a combination of levothyroxine (T4) and liothyronine (T3) is not recommended for most patients since it does not show an advantage over T4L monotherapy. However, in certain patients who remain symptomatic under replacement therapy with T4L and thyroid stimulating hormone (TSH) within the reference values, combined treatment with T4 and T3 can be tested.Clinical case: Male, 39 years old, medical h...

ea0070ep265 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Diabetic gastroparesis as an important comorbidity factor: About a clinical case

Veríssimo David , Faustino Diogo , Lopes da Costa Inês , Pires Pedro , Marques Carmen , Almeida Júlio

Introduction: Gastroparesis associated with diabetic autonomic neuropathy is an underdiagnosed complication, although relatively common in diabetes. It is more prevalent in type 1 Diabetes Mellitus (DM1) with more than ten years of disease and especially in patients with poor metabolic control.Clinical case: Female, 37 years old, DM1 with 17 years of evolution with poor metabolic control (HbA1c 9.3%) and several microvascular complications such as prolif...

ea0070aep721 | Pituitary and Neuroendocrinology | ECE2020

Septo-optic dysplasia with late-onset diagnosis: An uncommon presentation of a rare disease

Duarte Vitória , Ivo Catarina , Veríssimo David , Franco Sara , Bastos Filipa , Marcelino Mafalda , Vara Luiz Henrique , Portugal Jorge

Background: Septo-optic dysplasia (SOD), also known as de-Morsier syndrome, is a rare congenital disorder characterized by any combination of optic nerve hypoplasia, pituitary dysfunction and midline abnormalities of the brain. Clinical diagnosis requires the presence of at least two of the features. This disorder is equally prevalent in males and females, with a reported incidence of 1/10,000 live births. There is wide variation in the severity of the clinical features found....

ea0070ep269 | Endocrine-related Cancer | ECE2020

Multiple endocrine neoplasia: A case series of 7 families

Duarte Vitória , Ivo Catarina , Veríssimo David , Marcelino Mafalda , Vara Luiz Henrique , Franco Sara , Bastos Filipa , Manita Isabel , Raimundo Luisa , Portugal Jorge

Introduction: Multiple endocrine neoplasia (MEN) is a rare genetic syndrome characterized by occurrence of tumors involving two or more endocrine glands. Four types are described: MEN1, MEN2, MEN3 and the recently identi&#-1279;ed MEN4. Due to the complexity of the syndromes, it is difficult to manage these patients. Our objective was to describe the clinical features of individuals from 7 families with a diagnosis of MEN1 or MEN2 and identify current challenges in clinical pr...

ea0070ep499 | Thyroid | ECE2020

Endocrinopathies related to immune checkpoint inhibition: A clinical case presentation

Veríssimo David , Jácome de Castro Matilde , Ivo Catarina , Duarte Vitória , Marcelino Mafalda , Jácome de Castro João

Introduction: In the area of Immunotherapy, immunological checkpoints, such as CTLA-4, PD-1 or PD-L1, are membrane proteins involved in the immune response that, when inhibited, cause an increase in T cell activity and a consequent anti-tumor effect. However, this inhibition can also cause adverse effects, including endocrinopathies, such as thyroid dysfunction and hypophysitis.Clinical case: 59-year-old man, diagnosed with lung cancer, treated with nivo...

ea0073pep7.7 | Presented ePosters 7: Diabetes, Obesity, Metabolism and Nutrition | ECE2021

The impact of dipper profile on diabetes complications. A study of 197 diabetic patients

Duarte Vitória , Ivo Catarina , Veríssimo David , Silva Joao , Lopes Luis , Passos Dolores , Jácome Castro J , Marcelino Mafalda

BackgroundNon-dipping of nocturnal blood pressure is common among people with type 2 diabetes (T2D) and hypertension. Although the mechanism underlying the blunted nighttime response is unclear, insulin resistance is thought to play a role.AimsThis study aims to identify the pattern of nocturnal dipping of blood pressure in patients with T2D from a Portuguese population and its association with micro...

ea0073aep211 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Selective sodium-glucose cotransporter inhibitors 2 (isglt2) in patients with high risk of amputation

Mª del Carmen Serrano Laguna , Verónica Ávila Rubio , Sara León Utrero , Pablo José López-Ibarra Lozano

IntroductionThe use of iSGLT2 remains controversial in diabetic patients with peripheral arterial disease.ObjectivesAssess metabolic effect and risk of amputations of iSGLT2 in diabetic patients treated in the Multidisciplinary Unit of Diabetic Foot (MUDF) comparatively with a control group.Design and methodsRetrospective observational study in which the patients ...

ea0073aep650 | Thyroid | ECE2021

Myxedema coma in a COVID-19 patient

Cidade-Rodrigues Catarina , Dalila Martins Marta , Verónica Cardoso , Linhas Rita , Viveiros Filipa , Rogério Ruas , Ferraz Rita , Cunha Filipe

IntroductionMyxedema coma is a rare condition with an estimated incidence of 0.22 per million per year in the western world and a mortality rate around 30–50%. It can occur as the result of severe longstanding hypothyroidism or be precipitated by an acute event, such as infection. We present a rare case of myxedema coma in an elderly woman with SARS-CoV-2 infection.Case reportAn 82-year-old woman, with n...

ea0073ep76 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Hepatogenous diabetes: is it real?

David Veríssimo , Ivo Catarina , Vitória Duarte , Silva Joao , Lopes Luis , Passos Dolores , J Jácome Castro , Marcelino Mafalda

IntroductionDiabetes mellitus (DM) due to cirrhosis is described as hepatogenous diabetes (HD). Despite being frequently described in the literature, it is not recognized as an entity by the ADA/EASD.Case reportWoman, 70 years old, previous history of autoimmune hepatitis with Child-Turcotte-Pugh A cirrhosis (CTP-A) since 2018, arterial hypertension and overweight (BMI 29.1 kg/m2). No personal or f...

ea0073ep86 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Bariatric surgery: a shift in metabolic control

David Veríssimo , Ivo Catarina , Vitória Duarte , Silva Joao , Lopes Luis , Passos Dolores , J Jácome Castro , Marcelino Mafalda

IntroductionObesity is a chronic disease that is associated with several comorbidities, decreased quality of life, and increased mortality rate. Bariatric surgery is the most effective therapy for obese patients with class III and class II with metabolic diseases. Its effectiveness is not only related to the weight reduction, but also to the improvement of the metabolic profile. The aim of this study is to characterize the effects of gastroplasty with Ro...