Searchable abstracts of presentations at key conferences in endocrinology

ea0021sig2.4 | Pituitary Special Interest Group Session | SFEBES2009

Future issues for GH replacement in adults

Popovic Vera

Growth hormone (GH) deficient adults present with a wide spectrum of clinical presentations commonly called GHD syndrome. Detection of GHD is important especially as successful GH replacement therapy ameliorates many symptoms of the GHD syndrome and is accompanied by a significant improvement in quality of life (QoL) in GHD patients. GH therapy has been available for adults in the last twenty years and the results from large pharmaco-epidemiological follow ups under GH treatme...

ea0037ep1205 | Clinical Cases–Pituitary/Adrenal | ECE2015

Bilaterally slipped capital femoral epiphysis in growth hormone–deficient patient: osteosynthesis also needs the oestrogen epiphyseal fusion- case report

Tesic Dragan , Mitrovic Milena , Vlaski Jovan , Damjanovic Svetozar , Popovic Vera

Introduction: Growth without growth hormone is seen also in patient with craniopharyngioma. We just speculate what anabolic factors might be involved in this process. However, oestrogen through its receptors lead to epiphyseal fusion. In this case report we would like to present the patient with bilateral slipped femoral epiphysis (SFE) and interventions made at tertiary health care level.Case report: 20-years-old female, operated from craniopharyngioma ...

ea0035p851 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

What is in the sella while spying on cancer? The role of FDG–PET/CT in differential diagnosis of sellar mass during staging for malignant disease

Miljic Dragana , Pekic Sandra , Doknic Mirjana , Stojanovic Marko , Popovic Vera

Positron emission combined with computed tomography using 18F-deoxy-glucose (FDG–PET/CT) is increasingly used in the staging and detection of malignant disease. Normal pituitary is not visualized by routine FDG–PET/CT and its radiological evaluation relies predominantly on magnetic resonance imaging (MRI). The role of FDG–PET/CT in differential diagnosis of sellar mass, in patients investigated for malignant disease, will be discussed.<p class="ab...

ea0032p897 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Serum GH but not IGF1 levels correlate with body composition parameters in both men and women with active acromegaly

Stojanovic Marko , Miljic Dragana , Pekic Sandra , Doknic Mirjana , Popovic Vera

Introduction: Generously supported by IPSEN)-->Active acromegaly is reported to be associated with considerable body composition changes, with significant lean body mass changes found only in men.Patients and methods: In patients with active acromegaly (n=40) 24 females and 16 males, 48.9±6.4 years old, with BMI of 28.04±1.27 kg/m2, diagnosed 4.15±1.09 years ago, body composit...

ea0032p942 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Clinical characteristics of patients with congenital hypopituitarism in advanced age

Doknic Mirjana , Pekic Sandra , Miljic Dragana , Stojanovic Marko , Popovic Vera

Background: Generously supported by IPSEN)-->Hypopituitarism is considered to be a risk factor for cardiovascular disease and early death in humans. However, some studies showed that most patients with isolated GH deficiency or combined pituitary hormonal deficiency due to gene mutations (PROP 1, GH receptors gene, GH-1 gene) can survive to advanced age.Aim: To collect clinical data on patients with congenital ...

ea0049oc12.2 | Pituitary Clinical | ECE2017

Use of temozolomide in a large cohort of patients with aggressive pituitary tumours and pituitary carcinomas: Results from a European Society of Endocrinology (ESE) survey

McCormack Ann , Dekkers Olaf M , Petersenn Stephan , Popovic Vera , Trouillas Jacqueline , Raverot Gerald , Burman Pia

Objective: To collect clinical and treatment outcome data in a large patient cohort, and specifically to report experience with temozolomide (TMZ).Design: Cohort study based on an electronic survey open for participation to ESE members Dec 2015-Nov 2016.Results: Reports on 167 patients, 40 pituitary carcinomas, and 127 aggressive pituitary tumours were obtained. Median age at diagnosis was 43 (range 4–79) years. 59% of tumours...

ea0049ep953 | Pituitary - Clinical | ECE2017

Impact of etiology, age and gender on onset and severity of hyponatremia in patients with hypopituitarism

Miljic Dragana , Pekic Sandra , Doknic Mirjana , Nikolic-Djurovic Marina , Stojanovic Marko , Popovic Vera , Petakov Milan

Hyponatremia can unmask hypopituitarism and secondary adrenal insufficiency due to potent non-osmotic stimulation of vasopressin release under stressful conditions. Patients and methods: In a retrospective study 25 patients (13f/12m, age 58.9±18.6 years) with hyponatremia (119.7±10.5 mmol/l) were identified among 260 in-patients treated for hypopituitarism in our department over a decade. Results: Hyponatremia was recorded in 9.6% of our patients. In 84% it was the k...

ea0044p161 | Neuroendocrinology and pituitary | SFEBES2016

Bone turnover is significantly increased in patients with active acromegaly while bone mineral density remains normal

Stojanovic Marko , Miljic Dragana , Pekic Sandra , Doknic Mirjana , Petakov Milan , Popovic Vera

Introduction: Skeletal complications are among most persistent and invalidating systemic impacts of acromegaly. Assessment of bone health in acromegaly by dual-X-ray absorptiometry (DXA) alone might be insufficient or even misleading.Patients and methods: Patients with acromegaly (n=170) were classified as active (n=104), operatively cured (n=34) or medically controlled (n=32). We excluded patients with metabolic bone ...

ea0041ep882 | Pituitary - Clinical | ECE2016

Metabolic state in ACTH insufficient & ACTH sufficient patients with hypopituitarism not treated for growth hormone deficiency (GHD): a comparative study

Miljic Dragana , Pekic Sandra , Doknic Mirjana , Stojanovic Marko , Petakov Milan , Popovic Vera

Background: Inadequate glucocorticoid (GC) replacement may be associated with overexposure to GC, which can adversely influence metabolic and cardio-vascular state of hypopituitary growth hormone deficient adult patients (A-GHD). In this study we compared metabolic profile of ACTH insufficient and sufficient patients in A-GHD not treated with GH.Patients and methods: A cohort of 260 patients (age 48.6±12 years and BMI 28.7±6.6 kg/m2)...