Endocrine Abstracts

In the last years an increasing incidence of cardiovascular diseases (CVD) has been reported in young adults (18-45 yrs), probably accounted by the significant increase in CV risk (CVR) factors. Observational and interventional studies, mainly focused on middle-aged and elderly men, demonstrated that metabolic CVR (mCVR) factors and CVD manifestations are common in hypogonadal men and, conversely, testosterone deficiency is highly prevalent in metabolic disorders; the lack of ...

Polycystic ovary syndrome (PCOS) is characterized by menstrual irregularities and clinical and biochemical hyperandrogenism, and is associated with insulin resistance, visceral obesity and metabolic disorders. The aim of the current study was to compare the effects of inositol isomers (INO) and metformin (MET) on the clinical, metabolic and hormonal aspects of PCOS. In 94 PCOS women, clinical (weight, BMI, waist circumference - WC, menstrual intervals, Ferriman-Gallway score -...

Prolactin (PRL) exerts independent hypertrophic effects on prostate in in vivo and in vitro experimental models, and prostatic PRL receptors are known to activate cell proliferation pathways such as MAPK and STAT. Nevertheless, in men with hyperprolactinemia the risk of prostate cancer has been found reduced suggesting a role of concomitant hypogonadism. Chronic cabergoline treatment generally normalizes PRL treatment and improves gonadal function. The curren...

Fertility represents a major concern in patients with acromegaly and the peculiar PCOS-like condition is commonly found in acromegalic women. The current retrospective study aimed at investigating gonadal function and fertility rate in acromegalic women with disease onset (DO) within the reproductive age. In 50 women hormonal parameters and gynecological ultrasound were evaluated at diagnosis (DD) and after disease control (DC). Data about menstrual disturbances (MD), pregnanc...

Rationale: The gluco-metabolic changes during pregnancy significantly impact women’s sexual behavior. This study aimed to define the relationship between metabolic health and sexual function, along with human circadian rhythms and sleep quality during pregnancy.Methods: This study included 57 pregnant women (14 evaluated at first trimester, G1; 18 at second trimester, G2, and 25 at third trimester, G3). Among groups, no difference between age, gesta...

The current study evaluated the impact of metabolic and hormonal alterations on sexual and psychological function in women with Polycystic Ovary Syndrome (PCOS). Fifty consecutive women aged 24.16±5.97 years with a diagnosis of PCOS were recruited; metabolic and hormonal parameters were measured and questionnaires related to sexual function (Female Sexual Function Index-FSFI) and psychological traits (Middlesex Hospital Questionnaire-MHQ, Body Uneasiness Test A and B-BUT A ...

Campania Region has been facing waste management crisis since 1980, characterized by urban, toxic and industrial waste illegal disposal, burying and incineration. Cadmium (Cd) is consistently shown to affect male reproductive function by multiple mechanisms, mostly elucidated in experimental models. The aim of the current single-center, observational, cross-sectional cohort study was to evaluate the prevalence of testis morphostructural alterations in a large cohort of men liv...