Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep368 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Is MGP an inflammatory marker?

Schweighofer Natascha , Colantonio Caterina , Haudum Christoph W , Hutz Barbara , Kolesnik Ewald , Schmidt Albrecht , Zirlik Andreas , Pieber Thomas R , Verheyen Nicolas , Obermayer-Pietsch Barbara

Matrix-GLA-protein (MGP) was repeatedly associated with inflammation markers during the last decade. It is expressed in leucocytes and is a regulator of immune response. Due to posttranslational modification, there are 4 forms. The form responsible for immunomodulation is still unknown. Since the predicted active form - carboxylated, phosphorylated MGP - is not directly associated with immunomodulation, we aimed to investigate the association of dp-ucMGP (dephosphorylated, unc...

ea0081ep861 | Reproductive and Developmental Endocrinology | ECE2022

Associations of serum AMH levels and hormonal, metabolic and cardiovascular parameters in adult men

Tandl Veronika , Colantonio Caterina , Haudum Christoph W , Hutz Barbara , Kolesnik Ewald , Schmidt Albrecht , Zirlik Andreas , Verheyen Nicolas , Pieber Thomas R , Obermayer-Pietsch Barbara

Background: Anti-Müllerian hormone (AMH) is well known for its association with ovarian follicular count and ovarian reserve in general as well as for its recruitment of primordial follicles in women. With an explicit decrease in menopause, it is mainly used for clinical questions from in-vitro-fertilisation to polycystic ovary syndrome. Interestingly, AMH levels in men are quite high during lifetime, but there is only few data about its relevance and potential effects in...

ea0090p630 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

Urinary C-peptide to creatinine ratio (UCPCR) as indicator for metabolic risk in apparently healthy adults - a BioPersMed cohort study

Reintar Sharmaine , Pochhacker Magdalena , Obermayer Anna , Eberhard Katharina , Zirlik Andreas , Verheyen Nicolas , Haudum Christoph , Pieber Thomas , Sourij Harald , Obermayer-Pietsch Barbara

Background: C-peptide consists of 31 amino acids, synthesized in the beta cells of the pancreas and co-secreted along with insulin. Hence, serum C-peptide may be the preferred diagnostic biomarker for evaluating beta cell function compared to insulin. The urinary C-peptide to creatinine ratio (UCPCR) recently gained attention as a non-invasive biomarker for evaluating and monitoring metabolic risk. In this study, we aimed to characterize guiding values of UCPCR in healthy indi...

ea0090p545 | Late-Breaking | ECE2023

AMH in men: Higher serum levels associated with healthy male aging

Tandl Veronika , Haudum Christoph W. , Eberhard Katharina , Hutz Barbara , Kolesnik Ewald , Schmidt Albrecht , Zirlik Andreas , von Lewinski Dirk , Scherr Daniel , Verheyen Nicolas , Pieber Thomas R. , Obermayer-Pietsch Barbara

Anti-Müllerian hormone (AMH), known for its role in fetal development and female reproduction, is also present in adult and elderly men in considerable amounts. In recent years, controversial findings regarding relations to age, other hormones, and BMI (possibly based on a dilutional effect due to higher blood volume) have been discussed. To date, little is known of its clinical relevance in this population. We aimed to further investigate AMH levels in an aging male popu...

ea0081rc11.7 | Rapid Communications 11: Thyroid 2 | ECE2022

Altered expression profiles of miR-22-5p and miR-142-3p display Hashimoto´s disease and are associated with thyroid antibodies

Trummer Olivia , Foszl Ines , Schweighofer Natascha , Arifi Edi , Haudum Christoph , Reintar Sharmaine , Pilz Stefan , Theiler-Schwetz Verena , Trummer Christian , Zirlik Andreas , Schmidt Albrecht , Colantonio Caterina , Kolesnik Ewald , Verheyen Nicolas , Pieber Thomas , Obermayer-Pietsch Barbara

Background: HashimotoÂ’s thyroiditis (HT), the most prevalent autoimmune disorder of the thyroid (AITD) is characterized by the presence of circulating autoantibodies, induced by a not fully understood dysregulation of the immune system. MicroRNAs (miRNAs) are small noncoding RNAs, which can play a pivotal role in immune functions and the development of autoimmunity. The aim of the present investigation was to evaluate whether a panel of nine selected miRNAs differs in ser...

ea0090p77 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

En route to sarcopenia biomarkers: dp-ucMGP in relation to muscle mass and function

Tandl Veronika , Schweighofer Natascha , Trummer Olivia , Haudum Christoph W. , Lind Alice F. , Kolesnik Ewald , Mursic Ines , Scherr Daniel , Zirlik Andreas , Pieber Thomas R. , Verheyen Nicolas D. , Obermayer-Pietsch Barbara

Sarcopenia is characterized by progressive loss of both mass and function of skeletal muscle when ageing. It poses a serious issue for healthcare systems, as it is associated with increased risk of falls, osteoporosis, and mortality. To date, no ideal serum biomarkers for the diagnosis of this complex condition have been identified. Matrix-GLA-protein (MGP), primarily known as a vitamin K dependent calcification inhibitor, is present and active in bone, muscle, and adipose tis...

ea0063p409 | Adrenal and Neuroendocrine Tumours 2 | ECE2019

Diagnostic accuracy of the aldosterone to active renin ratio in detecting primary aldosteronism: the graz endocrine causes of hypertension (GECOH) study

Pilz Stefan , Keppel Martin , Trummer Christian , Theiler-Schwetz Verena , Pandis Marlene , Borzan Valentin , Pittrof Matthias , Obermayer-Pietsch Barbara , Grubler Martin R , Verheyen Nicolas , Stepan Vinzenz , Meinitzer Andreas , Voelkl Jakob , Marz Winfried , Tomaschitz Andreas

Context: The aldosterone to active renin ratio (AARR) is the recommended screening test for primary aldosteronism (PA), but prospective study data on its sensitivity and specificity are sparse.Objective: We investigated the diagnostic accuracy of the AARR for detecting PA.Design: This is a prospective diagnostic accuracy study.Setting: This study was conducted from February 2009 to August 2015 at the outpatie...

ea0056p308 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2018

Soluble ST2, a promising cardiovascular biomarker, is associated with parameters of glucose and bone metabolism in subjects at cardiovascular risk

Francic Vito , Gaksch Martin , Schwetz Verena , Trummer Christian , Pandis Marlene , Aberer Felix , Grubler Martin , Verheyen Nicolas D , Marz Winfried , Pieber Thomas R , Tomaschitz Andreas , Pilz Stefan , Obermayer-Pietsch Barbara

Introduction: Soluble ST2 (sST2) is the truncated soluble form of the ST2 receptor in the circulation. It is a decoy receptor of IL-33 and thereby inhibits the effects of IL-33/ST2 signaling. Elevated levels of sST2 have been associated with various adverse cardiovascular outcomes. Recently, potential associations of sST2 with obesity and type 2 diabetes mellitus (T2DM) have been described in the general population. In this study, we determined possible cross-sectional associa...