Searchable abstracts of presentations at key conferences in endocrinology

ea0037s17.1 | Diabetes and bone (<emphasis role="italic">Endorsed by the European Journal of Endocrinology</emphasis>) | ECE2015

Diabetes and osteoporosis -- cause for concern?

Vestergaard Peter

Background: Diabetes and osteoporosis are both frequent conditions, a link may thus put a substantial number of patients at risk of fragility fractures and the consequences of these such as pain, disability, and increased mortality. Skeletal fragility and osteoporosis may represent a hitherto overlooked complication of diabetes in line with say diabetic eye disease, diabetic nephropathy etc.Findings: An increased risk of fractures has been observed in bo...

ea0032p641 | Male reproduction | ECE2013

Mortality is increased in men treated with testosterone compared to age and sex-matched controls

Karmisholt Jesper , Eriksen Stine , Rungby Jorgen , Vestergaard Peter

Background: Symptomatic hypogonadism is frequent and associated with increased risk of cardiovascular events. Hypogonadism is often treated with testosterone replacement. In a recent meta-analysis on adverse events in randomised placebo controlled testosterone replacement trials (RPCT), no differences between testosterone or placebo/non-intervention groups with regards to cardiovascular events or risk factors was observed. Conversely, a contemporary RPCT in elderly immobile pa...

ea0081oc8.2 | Oral Communications 8: Calcium and Bone | ECE2022

SGLT2 inhibitor treatment does not increase risk of osteoporotic fractures compared to GLP-1 receptor agonists: a Danish population-based cohort study

Al-Mashhadi Zheer Kejlberg , Viggers Rikke , Starup-Linde Jakob , Vestergaard Peter , Gregersen Soren

Background: Type 2 diabetes mellitus (T2D) is associated with an increased risk of fractures. Research on the effects of sodium-glucose cotransporter 2 (SGLT-2) inhibitors is scarce and unsettled. We aimed to investigate the risk of major osteoporotic fractures (MOF) – i.e., hip, vertebral, humerus, and forearm fractures – with SGLT2 inhibitors compared to glucagon-like peptide 1 (GLP-1) receptor agonists when either is used in combination with metformin.<p class...

ea0084ps3-13-116 | Pregnancy & Iodine | ETA2022

Iodine status in danish pregnant women after an increase in iodine fortification: a regional study

Knosgaard Louise , Andersen Stig , Bo Hansen Annebirthe , Nodgaard Sorensen Anne , Vestergaard Peter , Linding Andersen Stine

Objectives: The Danish population was previously iodine deficient with regional differences, and a mandatory iodine fortification of salt was introduced more than 20 years ago. Despite iodine fortification and frequent use of iodine-containing supplements, the iodine status in Danish pregnant women was insufficient when evaluated in 2012 (median urinary iodine concentration (UIC): 101 µg/l). From July 1, 2019 the authorities implemented a mandatory increase from 13 to 20 ...

ea0081p512 | Late-Breaking | ECE2022

Changes in acromegaly presentation and treatment over a three-decade period

Aagaard Charlotte , S Christophersen Amanda , Finnerup Susanne , Rosendal Christian , Vestergaard Peter , Karmisholt Jesper , H Nielsen Eigil , Dal Jakob

Objective: To study time-dependent changes in the prevalence and patient characteristics of acromegaly, as well as to access the impact of changes in treatment on disease control.Methods: A total of 107 patients with acromegaly were identified by healthcare registries and subsequently validated by patient chart review over a three-decade period (1992-2021).Results: The prevalence of acromegaly significantly increased throughout the...

ea0070aep777 | Pituitary and Neuroendocrinology | ECE2020

Acromegaly is associated with reduced socioeconomic status and more so in female patients: A nationwide population-based study

Dal Jakob , Nielsen Eigil H , Feldt-Rasmussen Ulla , Andersen Marianne , Feltoft Claus , Vestergaard Peter , Stochholm Kirstine , Otto Jorgensen Jens

Context: Acromegaly is a rare and insidious disease associated with severe somatic morbidity but data on socioeconomic status are scarce.Objective: To study the socioeconomic status in acromegaly in a population based, nationwide follow-up study.Patients and Methods: All incident cases of acromegaly (n = 576) during the period 1997–2010 were included, representing 10.116 years at risk. For every patient, 100 pers...

ea0070aep1094 | Hot topics (including COVID-19) | ECE2020

Identification of thyroid disease in pregnant women varies by analytical method and type of thyroid function test

Linding Andersen Stine , Astrup Christensen Peter , Knøsgaard Louise , Andersen Stig , Handberg Aase , Bo Hansen Annebirthe , Vestergaard Peter

Objective: Physiological alterations challenge the assessment of maternal thyroid function in pregnancy. It remains uncertain how the reference ranges vary by week of pregnancy, and how the classification of maternal thyroid disease vary by analytical method and type of thyroid function test.Method: Consecutively collectedserum samples from 6.282 pregnant women in the North Denmark Region, 2011–2013, were used for the measurement of thyrotropin (TS...

ea0092ps3-23-01 | Pregnancy | ETA2023

TSH elevation before or after a pregnancy according to unidentified maternal thyroid function and thyroid autoantibody status in the early pregnancy: A study of 13,664 danish pregnant women

Linding Andersen Stine , Hjelm Lundgaard Maja , Maria Uldall Torp Nanna , Lykkeboe Simon , Carle Allan , Karmisholt Jesper , Bulow Pedersen Inge , Vestergaard Peter , Andersen Stig

Objectives: One of the risk-based screening criteria for thyroid disease in pregnancy is previous abnormal thyroid function or thyroid autoantibody-positivity. We speculated on the frequency and results of thyroid function testing in women of fertile age as part of routine care before and after a pregnancy.Methods: The North Denmark Region Pregnancy Cohort includes retrospective assessment of thyroid function and thyroid autoantibodies (ADVIA Centaur XPT...

ea0084op-05-23 | Oral Session 5: Autoimmunity | ETA2022

Cut-offs for thyroid peroxidase and thyroglobulin antibodies in early pregnancy are not similar and may differ from non-pregnant individuals: evidence from 10,905 danish pregnant women

Linding Andersen Stine , Henrik Bruun Niels , Astrup Christensen Peter , Lykkeboe Simon , Handberg Aase , Bo Hansen Annebirthe , Berg Hjelm Maja , Knosgaard Louise , Maria Uldall Torp Nanna , Carle Allan , Scott Karmisholt Jesper , Bulow Pedersen Inge , Vestergaard Peter , Andersen Stig

Objectives: Thyroid disease in women of reproductive age is predominantly of autoimmune origin, and thyroid peroxidase antibodies (TPO-Ab) as well as thyroglobulin antibodies (Tg-Ab) are key markers of autoimmune hypothyroidism. Adding to this, much focus in pregnancy is on euthyroid women who are positive for thyroid autoantibodies. The observational findings are diverse, and evidence to substantiate the applied cut-offs for definition of thyroid autoantibody-positivity in ea...