Searchable abstracts of presentations at key conferences in endocrinology

ea0020p577 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

Two repeated restraint stress paradigms differing in duration and frequency result in similar levels of HPA habituation, but differences in neuropeptide expression and testosterone levels

Gray Megan , Bingham Brenda , Viau Victor

The dampening of hypothalamic┬ľpituitary┬ľadrenal (HPA) axis responses to a repeated stress is termed HPA habituation. We investigated here the effects of two commonly used repeated restraint stress paradigms, in which rats are exposed either to 10 episodes of 0.5 h restraint or 5 episodes of 3 h restraint. We compared ACTH, corticosterone, and testosterone responses, as well as corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) mRNA levels within bra...

ea0020p607 | Neuroendocrinology, Pituitary and Behaviour | ECE2009

The role of androgen receptors in the medial amygdala on biosynthesis and stress-induced cellular activation of the paraventricular nucleus of the hypothalamus

Bingham Brenda , Gray Megan , Viau Victor

Although it is becoming increasingly clear that testosterone exerts an inhibitory influence on stress-induced adrenocorticotropin (ACTH) and corticosterone release, where and how this occurs in the brain remains poorly understood. We previously determined that androgen receptors are not distributed within anterior pituitary communicating neurons of the paraventricular nucleus (PVN) of the hypothalamus (Bingham et al. J Comp Neurol 2006). However, they are contained with...

ea0065oc5.1 | Adrenal and Cardiovascular | SFEBES2019

Central role for corticosteroid-binding globulin in rat HPA axis sexual dimorphism

Toews Julia , Hill Lesley , Philippe Tristan , Rege Juilee , Rainey William , Viau Victor , Hammond Geoffrey

Many organs are functionally sexually dimorphic, resulting in profound differences in the activity of several physiological systems, including the hypothalamic-pituitary-adrenal (HPA) axis. The rodent HPA axis matures post-weaning, characterized by parallel increments in adrenal weight, adrenal cortical size and corticosterone secretion. Between postnatal days (PND) 30 to 45, these parameters increase to a greater extent in females compared to males. Over this same interval, h...