Searchable abstracts of presentations at key conferences in endocrinology

ea0016p514 | Obesity | ECE2008

Relationship among stress, weight gain and the activity of the hypothalamic-pituitary-adrenal (HPA) axis

Marconi Valentina , Vicennati Valentina , Corvaglia Stefania , Zampighi Adria , Agostino Romina Di , Pasquali Renato

The aim of this study was: 1) to determine whether there is a correlation between a stressful event, such as the mourning, the hyperactivity of HPA axis, and the fast weight gain 2) to assess whether there is a specific parameter that can predict the susceptibility of individuals to develop metabolic syndrome following a stressful event. We investigated 80 obese women, aged between 23 and 67 years; each subject underwent a clinical evaluation, an OGTT and biochemical, metaboli...

ea0016p513 | Obesity | ECE2008

Prevalence and characterization of metabolic syndrome (MS) in different classes of obesity and related endocrine factors

Genghini Silvia , Vicennati Valentina , Zampighi Adria , Corvaglia Stefania , Pasquali Renato

The aim of study was to evaluate in a group of obese women the prevalence of the metabolic syndrome, defined accordingly to the International Diabetes Federation, of single factors of the syndrome and the correlations with endocrine factors. We evaluated 351 women, 262 overweight-obese and 89 normal weight controls, which underwent physical, biochemical and hormonal evaluation. The prevalence of MS in obese and overweight subjects was 62.3%; the prevalence increased significan...

ea0081rc12.6 | Rapid Communications 12: Reproductive and Developmental Endocrinology | ECE2022

Is Turner syndrome at risk for thyroid carcinoma?

Belardinelli Elisabetta , Dionese Paola , Cecchetti Carolina , Vicennati Valentina , Repaci Andrea , Pagotto Uberto , Gambineri Alessandra

Background: Many questions concerning Turner Syndrome (TS) remain unresolved, such as the long-term complications and, therefore, the optimal care setting for adults. Most controversials regard tumors. Very few data are available on thyroid carcinoma and no specific screening protocol of monitoring is advised in the current official guidelines. This long-term cohort study was primarily aimed at estimating the incidence and time to comorbid conditions along the life course, inc...

ea0063p515 | Calcium and Bone 2 | ECE2019

Denosumab, alendronate and zoledronate failure to suppress bone resorption markers in a woman affected by severe osteoporosis and subclinical hypercortisolism due to an adrenal adenoma: A case report

Zavatta Guido , Preiato Valentina Lo , Vandi Giulia , Vicennati Valentina , Di Dalmazi Guido , Pagotto Uberto , Altieri Paola

Context: ß-CTX are considered useful markers of response to denosumab and other anti-resorbtive treatments for osteoporosis. We report an unusual case of a completely absent effect of both denosumab and bisphosphonates on bone resorption markers.Case description: In 2017 a 74-year-old woman sought medical attention at the Endocrinology Unit of Policlinico di Sant’Orsola for the evaluation of an adrenal adenoma associated with osteoporosis. Meno...

ea0041ep23 | Adrenal cortex (to include Cushing's) | ECE2016

Ascending aorta dilatation in primary aldosteronism: a new deleterious consequence of aldosterone excess

Vicennati Valentina , Zavatta Guido , Pagotto Uberto , Casadio Elena , Di Dalmazi Guido , Eleonora Rinaldi , Pasquali Renato

Introduction: Primary aldosteronism (PA) features a higher prevalence of cardiovascular events and renal complications as compared with essential hypertension. The effects of aldosterone excess on ascending aorta have never been investigated in human subjects.Methods: From August 2014 to December 2015, we enrolled forty-seven consecutive PA outpatients who had not undergone surgery of the adrenal mass. Hypercortisolism and pheochromocytoma were excluded....

ea0032p16 | Adrenal cortex | ECE2013

Mortality in long-term follow-up patients with progressively increased patterns of subclinical cortisol hypersecretion

Di Dalmazi Guido , Vicennati Valentina , Paccapelo Alexandro , Pagotto Uberto , Pasquali Renato

Background: Subclinical Cushing’s syndrome (SCS) is defined as alterations in hypothalamic–pituitary–adrenal axis without classic signs or symptoms of glucocorticoid excess. This condition has been associated to increased risk of adverse metabolic and cardiovascular outcomes, independently of other potential risk factors. However, is still not known if this condition could lead to a higher mortality respect to non-secreting adrenal masses (NSA).<p class="abs...

ea0022p40 | Adrenal | ECE2010

Higher cortisol response to glucose load in patient with adrenal adenomas and subclinical Cushing (SC)

Vicennati Valentina , di Dalmazi Guido , Casadio Elena , Repaci Andrea , Pagotto Uberto , Pasquali Renato

Aims: SC can be discovered in 5–20% of the incidentalomas. Subclinical secretion is defined by the failure to suppress plasma cortisol after 1 mg-overnight dexamethasone <50 nmol/l, but there is no agreement in literature. The aim of our study was to evaluate cortisol response to oral glucose tolerance test (OGTT) as potential marker of autonomous activity of these adenomas.Methods: Ninety subjects, 47 females and 43 males, underwent the protoco...

ea0022p426 | Endocrine tumours &amp; neoplasia (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Adrenocortical carcinoma (ACC): our experience

Di Dalmazi Guido , Ripani Raffaella , Casadio Elena , Vicennati Valentina , Pagotto Uberto , Pasquali Renato

Aim: ACC is an extremely rare heterogeneous aggressive disease. Clinical presentation are various. The prognosis is very poor. There are limited data to define prognostic markers for survival beyond stage.The aim of this study is to describe the experience of our institution with patients affected by ACC.Material and methods: This study was performed on 13 patients aged between 26 and 76 years, from 1992 to 2009 who turned to our I...

ea0016p503 | Obesity | ECE2008

Expression of the different components of the endocannabinoid system (ECs) in morbid obesity

Vicennati Valentina , Pagotto Uberto , Cervino Cristina , Amenta Enrico , Cariani Stefano , Pasquali Renato

Visceral fat (VAT) may represent the more important site of endocannabinoid dysregulation in obesity. No data are available on the expression of the ECs in morbid obesity. Eleven morbidly obese women, who underwent bariatric surgery, were enrolled and paired samples of VAT and subcutaneous fat tissue (SAT) were obtained from each patient. Real-Time PCR for the gene expression levels of cannabinoid type 1 (CB1) receptor, N-acyl-phosphatidil-ethanolamine (NAPE), and fatty...

ea0014p214 | (1) | ECE2007

Effects of pharmacological stimulation or blockade of cannabinoid receptor type 1 (CB1) on gene expression in mouse cultured adipocyte cells

Bellocchio Luigi , Cervino Cristina , Fanelli Flaminia , Vicennati Valentina , Pasquali Renato , Pagotto Uberto

The endocannabinoid system has recently emerged as an important modulator of several functions of adipose tissue by altering cell proliferation and gene expression. In this work, we investigated the effects of CB1 activation/blockade in mouse 3T3-L1 adypocite cells by using WIN55,212, a CB1/CB2 agonist and rimonabant, a specific CB1 antagonist, in different experimental settings such as acute treatment on pre-adipocytes and on mature adipocytes, and chronic treatment during di...