Searchable abstracts of presentations at key conferences in endocrinology

ea0020p684 | Signal Transduction | ECE2009

Nuclear orphan receptor Nur77 is a mediator of p53-dependent apoptotic response

Sanguinetti Dolores , Carneiro Carmen , Martinez Gloria , Dominguez Fernando , Vidal Anxo

Nur77 is a nuclear orphan receptor belonging to the steroid receptor superfamily. A role for Nur77 has been described in proliferation, differentiation and apoptosis, as a result of its induction in response to multiple signal transduction pathways. Previous studies have suggested that physical interaction between Nur77 and the tumor suppressor p53 can prevent p53 ubiquination and subsequent degradation by hMdm2. This suggests a possible role for Nur77 as a regulator of p53-de...

ea0032p726 | Obesity | ECE2013

The lack of Nur77 affects energy and glucose metabolism in females fed on high fat diet

Sieira Sonia Perez , Martinez Gloria , Porteiro Begona , Lopez Miguel , Vidal Anxo , Nogueiras Ruben , Dieguez Carlos

Nur77 is an orphan nuclear receptor included in the NR4A family. This protein has been studied as a transcriptional regulator of glucose metabolism in different tissues. We aimed to investigate the endogenous role of Nur77 on energy and metabolic homeostasis. For this purpose, we used male and female Nur77-deficient mice and their wild-type littermates. We challenged them to standard diet and high fat diet, and analyzed different parameters involved in energy balance (food int...

ea0016p346 | Endocrine tumours | ECE2008

p107Rbl1 is an haploinsufficient tumor suppressor in mouse pituitary

Martinez Gloria , Carneiro Carmen , Estravis Miguel , Yeh Nancy , Koff Andrew , Vidal Anxo

The pocket protein family members, pRb, p107 and p130, are negative regulators of the cell cycle. But, while the role of pRB as a tumor suppressor has been extensively established, genetic inactivation of p107 or p130 is uncommon in tumors. Previous studies have shown that p130 cooperates with the CDK inhibitor p27Kip1 restricting proliferation of mouse intermediate lobe pituitary cells. Accordingly double knockout mice show higher incidence of pituitary tumors than single KO ...