Endocrine Abstracts

Background: On the basis of prior large epidemiologic and retrospective studies on treatment-related side effects, it appears that there are sex-based differences in the epidemiology of NENs and treatment-related side effects. The purpose of this study was to examine sex differences in incidence, diagnoses present during hospital stay, and mortality among patients with NENs.Methods: The NIS database was used to define an unweighted sample of patients wit...

Background: Significant advances have been made in the treatment of gastrointestinal (GI-) and pancreatic (P-) NENs. However, the use of immunotherapy is still limited, with most tumors considered immune “cold”. The cGAS-STING signaling pathway has emerged as a critical mediator of inflammation and immune-mediated responses, with pathway agonists under development for enhancing immunotherapy. In this study, we evaluated associations between cGAS-STING pathway activit...

Background: Evaluating treatment (Tx) Response in NETs using CT/MRI scans can be difficult. Previous studies, including the E2211, have shown improved progression-free survival (PFS) but no significant difference in Rp as measured by RECIST 1.1 (R1.1) criteria. Therefore, it is difficult to determine Tx effectiveness with short-term imaging, further complicated by differences in imaging protocols and inter-reader variability. Incorporating tumor density, using smaller threshol...