Searchable abstracts of presentations at key conferences in endocrinology

ea0063p258 | Pituitary and Neuroendocrinology 1 | ECE2019

Anterior pituitary insufficiency in clinically non-functioning pituitary microadenoma

Arcano Karina , Trivino Vanesa , Garcia-Sancho Paula , Diez Juan Jose , Cordido Fernando , Villabona Carles , Iglesias Pedro

Background: Systematic exploration for anterior pituitary deficiency in patients harboring pituitary microadenomas is not well defined. So far, little is known on the involvement of pituitary function in clinically non-functioning pituitary microadenomas (CNFPM).Objective: To evaluate the prevalence of anterior pituitary insufficiency, defined as at least one hormonal deficiency, in patients diagnosed of CNFPM.Patients and methods:...

ea0049ep891 | Neuroendocrinology | ECE2017

Clinical features and natural history of clinically non-functioning pituitary incidentalomas

Iglesias Pedro , Arcano Karina , Trivino Vanessa , Garcia-Sancho Paula , Diez Juan Jose , Cordido Fernando , Villabona Carles

Objetive: To assess the clinical features of incidental clinically non-functioning pituitary adenoma (NFPA) and to analyze its natural history.Methods: A multicenter retrospective study in patients with NFPA followed-up from 1992 to 2015 was performed.Results: Fifty-seven patients were studied (29 women (50.9%); age 55.8±16.7 years. 43.9% were older than 60 years, 40.3% belonged to the age group of 40–60 years and 15.8% w...

ea0041ep734 | Neuroendocrinology | ECE2016

Serum concentrations of glucose, cholesterol and triglyceride in men with prolactinoma treated with cabergoline

Dawid Maria del rocio , Arcano Karina , Diez Juan Jose , Villabona Carles , Bernal Carmen , Iglesias Pedro

Introduction: Hyperprolactinemia has been associated with several metabolic abnormalities both in glucose homeostasis, insulin sensitivity, and in lipid profile. Moreover, it has also been reported that many of them seem to improve after normalizing serum prolactin (PRL) concentrations.Objective: To study serum glucose, cholesterol and triglyceride in men with prolactinoma before and after chronic treatment with cabergoline.Patient...

ea0041ep750 | Neuroendocrinology | ECE2016

Nonfunctioning pituitary adenoma: a clinical and pathological study

Arcano Karina , Trivino Vanessa , Garcia Paula , Diez Juan Jose , Cordido Fernando , Villabona Carles , Iglesias Pedro

Objective: To assess clinical outcome after pituitary surgery in patients nonfunctioning pituitary adenomas (NFPA) surgically treated in the past 3 decades in three tertiary referral hospitals.Methods: A multicenter retrospective study on clinical and pathological characteristics, treatment patterns, and outcome in patients with NFPA periodically followed up in specialized neuroendocrinology units who underwent surgery in the period 1982–2015 was pe...

ea0014p277 | (1) | ECE2007

Adrenal incidentalomas: aberrant expression of hormone receptors (preliminary results)

Mena Elena , Sahun Manel , Alià Pedro , Navarro M Ángel , Soler Joan , Villabona Carles

Background: In some patients with adrenal tumors cortisol regulation may be under the control of abnormal or ectopic hormone receptors. The objective of this study is investigate the presence of these aberrant receptors in subjects with adrenal incidentaloma and biochemical criteria of subclinical hypercortisolism.Patients and methods: We studied seventeen patients with adrenal incidentalomas, ten patients with a unilateral tumor (age 48–70, M/F: 4/...

ea0056p797 | Pituitary - Clinical | ECE2018

Giant prolactinomas in men: clinical features and therapeutic outcomes

Arcano Karina , Jose Diez Juan , Rodriguez Victor , Bernal Carmen , Villabona Carles , Iglesias Pedro

Aims: To evaluate the clinical features and long-term therapeutic outcome of giant prolactinoma (gPRLoma) in men and to compare them with those of a group of male patients with non-gPRL macroprolactinomas (non-gPRLomas).Patients and methods: A retrospective and multicenter study of gPRLomas in men diagnosed in a 20-year period was performed. Clinical data and treatment outcome were registered. The diagnosis of gPRLoma was established when the maximal tum...

ea0063p954 | Diabetes, Obesity and Metabolism 3 | ECE2019

Doege-potter syndrome in patients with malignant extrapleural solitary fibrous tumor: a single center experience

Peiro Inmaculada , Iglesias Pedro , Diez Juan Jose , Martin-Liberal Juan , Garcia-del-Muro Xavier , Serrano Teresa , Villabona Carles

Introduction: Doege-Potter syndrome (DPS) is a rare paraneoplastic syndrome consistent in non-islet-cell tumor hypoglycemia associated with solitary fibrous tumor (SFT). Pathogenesis of hypoglycemia has been attributed to the production of insulin-like growth-factor-2 (IGF-2) by tumor cells. We report two DPS patients with metastatic extrapleural SFT.Case 1: A 42-year-old man with SFT of the mesocolon that had been operated in 2010, presented with metast...

ea0041ep247 | Clinical case reports - Pituitary/Adrenal | ECE2016

Pituitary adenoma associated with pheochromocytoma/paraganglioma

Guerrero Fernando , Arcano Karina , Marengo Agustina Pia , Robledo Mercedes , Diez Juan Jose , Lisbona Arturo , Iglesias Pedro , Villabona Carles

Background: Pituitary adenomas (PA) and pheochromocytomas/paraganglioma (pheo/PGL) can occur in the same patient due to coincidence or of shared pathogenesis. There is evidence that, at least in some cases, classical pheo/PGL predisposing genes, may also play a role in pituitary tumorigenesis. A new condition called ‘the three P Association’ (3PAs) for the combination of PA with pheo/PGL has been recently described in patients with or without succinate dehydrogenase ...

ea0056p118 | Endocrine tumours and neoplasia | ECE2018

Comparative study between familial and sporadic pheochromocytoma

Garcia-Sancho Paula , Marengo Agustina P. , Guerrero Fernando , Peiro Inmaculada , Santacruz Elisa , Jose Diez Juan , Iglesias Pedro , Villabona Carles

Introduction: Pheochromocytomas (Pheo) may appear sporadically (SPheo) or as an autosomal dominant inherited disease, named as familial PHEOs (FPheo). The latter are present in younger patients, and usually with multiple tumors, but may occur in patients with apparently simple sporadic tumors with no other syndromic features.Material and methods: Clinical data of all consecutive patients underwent surgery for Pheo over 35 years in two tertiary referral c...

ea0049ep88 | Adrenal medulla | ECE2017

Pheochromocytoma in neurofibromatosis type 1

Marengo Agustina Pia , Garcia-Sancho Paula , Guerrero Fernando , Peiro Inmaculada , Santacruz Elisa , Ortiz Andres , Diez Juan Jose , Iglesias Pedro , Villabona Carles

Background: Individuals with neurofibromatosis type-1 (NF1) carry an increased risk of pheochromocytoma (PHEO). Detection strategy is unknown but most experts recommend screening if hypertension develops.Objective: Report the characteristics of PHEO in patients with NF1 (NF1 group) and compare them with non-NF1-associated PHEO (non-NF1 group).Methods: Retrospective cohort study of patients undergoing PHEO resection in two Spanish t...