Searchable abstracts of presentations at key conferences in endocrinology

ea0048o6 | Oral Communications | SFEEU2017

Using Kisspeptin to assess GnRH function in an unusual case of primary amenorrhoea

Narayanaswamy Shakunthala , Vimalesvaran Sunitha , Yang Lisa , Prague Julia K , Miras Alexander D , Franks Stephen , Meeran Karim , Dhillo Waljit S

Case history: An 18-year-old Caucasian female presented with primary amenorrhoea after her younger sister aged 16 years old started menstruating. She had a normal childhood and progressed through puberty normally, with no past medical history or family history. BMI was 22.6 with a normal examination including secondary sexual characteristics (Tanner Stage 5) and no signs of hyperandrogenism.Investigations and Results: Bloods showed an elevated LH:FSH rat...

ea0044p208 | Reproduction | SFEBES2016

Anti-Müllerian Hormone (AMH) and Antral Follicle Count (AFC) are predictive markers in the assessment of patients with menstrual disturbance

Abbara Ali , Clarke Sophie , Roberts Rachel , Vimalesvaran Sunitha , Comninos Alexander , Christopoulos Georgios , Islam Rumana , Franks Steven , Trew Geoffrey , Dhillo Waljit

Background: Anti-Müllerian Hormone (AMH) and Antral Follicle Count (AFC) are both principally used as markers of ovarian reserve and available in all UK hospitals. The utility of these markers in the binary diagnosis of Polycystic Ovarian Syndrome (PCOS) by published criteria, such as Rotterdam, has been previously reported. We evaluated their utility in the evaluation of oligo/amenorrhoea in healthy young non-obese women.Methods: Women with both ov...

ea0044oc6.1 | Pregnancy and Reproductive Health | SFEBES2016

Two doses of kisspeptin improve oocyte maturation and implantation rates compared to a single kisspeptin injection during IVF treatment

Abbara Ali , Clarke Sophie , Islam Rumana , Prague Julia , Comninos Alexander , Narayanaswamy Shakunthala , Papadopolou Deborah , Roberts Rachel , Nesbitt Alexander , Izzi-Engbeaya Chioma , Vimalesvaran Sunitha , Ratnasabapathy Risheka , Salim Rehan , Lavery Stuart , Bloom Stephen , Trew Geoffrey , Dhillo Waljit

Background: In vitro fertilisation is an effective therapy for infertility, but can result in the potentially life-threatening complication, Ovarian Hyper-Stimulation Syndrome (OHSS). We have previously reported that a single injection of kisspeptin results in an LH surge of ~12–14 hrs duration, sufficient to safely induce oocyte maturation, but eliminate OHSS. However, the physiological LH surge in a normal menstrual cycle has a plateaux lasting 24–28 hrs. ...