Searchable abstracts of presentations at key conferences in endocrinology

ea0035p256 | Clinical case reports Pituitary/Adrenal | ECE2014

An unusual case of reversible empty sella

Triggiani Vincenzo , Giagulli Vito Angelo , Guastamacchia Edoardo

A 22-year-old female complaining about irregular menses associated to a slight increase of serum PRL and the recent onset of headache, nausea, dizziness, photophobia, occasional diplopia, visual impairment, anxiety and panic attacks was evaluated for the possible presence of a cerebral mass with intracranial hypertension. Fundoscopic examination and visual field were both normal. There was an empty sella with a flattened pituitary gland along the floor of the pituitary fossa a...

ea0014p296 | (1) | ECE2007

Thyroid nodules in the elderly: role of ultrasound (US) and ultrasound-guided fine-needle aspiration biopsy (US-FNAB)

Triggiani Vincenzo , Guastamacchia Edoardo , Resta Francesco , Sabba Carlo , Tafaro Emilio

The prevalence of thyroid nodules is increased in the elderly. The aim of this study was to evaluate the accuracy of US and US-FNAB in the diagnosis of thyroid cancer in a population of elderly subjects, all of whose thyroid nodules were subjected to US-FNAB, with no prior selection based on dimensions or echo-pattern. Over a three-year period, 276 consecutive patients (64 males and 212 [76.8%] females), aged 65 to 87 (mean 70±4.4), underwent US evaluation and US-FNAB of ...

ea0032p1002 | Thyroid (non-cancer) | ECE2013

Diagnosis of hypothyroidism is associated to an increased risk of acute decompensated heart failure occurrence, but not of mortality among heart failure outpatients

Triggiani Vincenzo , Iacoviello Massimo , Puzzovivo Agata , Antoncecchi Valeria , Angelo Giagulli Vito , Guastamacchia Edoardo , Favale Stefano

It has been demonstrated that hypothryoidism could affect the prognosis of patients with cardiovascular disease. The aim of this study was to better clarify the prognostic role of hypothyroidism in patients with chronic heart failure (CHF).We enrolled 384 consecutive outpatients (65±13 years, 296 males, NYHA 2.3±0.6, left ventricular ejection fraction, LVEF, 32±9%) with CHF (ESC criteria), in stable clinical conditions (at least 30 days) a...

ea0022p751 | Thyroid | ECE2010

Role of hypothyroidism in predicting a worse prognosis of heart failure outpatients treated with amiodarone

Triggiani Vincenzo , Iacoviello Massimo , Guastamacchia Edoardo , Guida Pietro , Forleo Cinzia , Puzzovivo Agata , Tafaro Emilio , Favale Stefano

Amiodarone, an iodine-containing antiarrhythmic drug frequently used in chronic heart failure (CHF) patients, is often the cause of primary hypothyroidism. It has not been well investigated, however, whether its use could lead to a poor prognosis in these patients by inducing and/or worsening thyroid function. The aim of this study was to evaluate the prognostic significance of hypothyroidism detection in CHF outpatients treated with amiodarone. Out of 355 patients affected by...

ea0020p124 | Thyroid | ECE2009

Prognostic role of sub-clinical hypothyroidism in chronic heart failure outpatients

Guastamacchia Edoardo , Triggiani Vincenzo , Iacoviello Massimo , Guida Pietro , Forleo Cinzia , Catanzaro Raffaella , Tafaro Emilio , Favale Stefano

The aim of this study was to evaluate the prognostic role of subclinical hypothyroidism in patients with chronic heart failure (CHF). We evaluated 338 consecutive outpatients (260 male; age 64±13) with stable CHF (NYHA class 2.3±0.6) receiving conventional therapy (ACE inhibitors and/or ARBs 93%, Beta-blockers 88%, Digitalis 26%, Diuretics 85%, Spironolactone 54%, Amiodarone 32%). The patients underwent a physical examination, electrocardiography and echocardiography...

ea0020p363 | Diabetes and Cardiovascular | ECE2009

Chemotherapy does not influence measures of glycaemic control in non-diabetic patients affected by acute leukaemia

Triggiani Vincenzo , Guastamacchia Edoardo , Liso Vincenzo , Specchia Giorgina , Resta Francesco , Sabba Carlo , Licchelli Brunella , Tafaro Emilio

Aim: Aim of the study was the evaluation of the effects of chemotherapy on insulin secretion and insulin sensitivity in patients affected by acute leukaemia.Materials and methods: Thirty-two non-diabetic patients (17 male, 15 female; age 51.1±17.4, range 16–76 years; BMI=25.1±3.7, range 18.4–32.8 kg/m2; 6=18% with a family history of diabetes mellitus) affected by acute leukaemia, 4 LLA (12.5%) and 28 LMA (87.5%), have been...

ea0081p355 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

GLP-1 receptor agonists and erectile dysfunction in diabetic men with and without hypogonadism: a 1- year retrospective observational study

Lisco Giuseppe , Isabella Ramunni Maria , De Pergola Giovanni , Jirillo Emilio , Guastamacchia Edoardo , Triggiani Vincenzo , Angelo Giagulli Vito

Background: Erectile dysfunction affects nearly half of men with type 2 diabetes (T2DM), and one-third of diabetic men have hypogonadism1. As an add-on to TRT in hypogonadal men with T2DM, Liraglutide may improve erectile function2, and dulaglutide decreased the incidence of moderate and severe ED in T2DM3.Study aims: To assess the GLP-1RA effect in T2DM men complaining of ED treated with both liraglutide and dulaglutide ...

ea0090p209 | Thyroid | ECE2023

The TNAPP web-based algorithm improves thyroid nodule management in clinical practice. A retrospective validation study

Lisco Giuseppe , Renzulli Giuseppina , Frasoldati Andrea , Guglielmi Rinaldo , Angelo Giagulli Vito , Guastamacchia Edoardo , R Garber Jeffrey , Triggiani Vincenzo , Papini Enrico

The detection of thyroid nodules has been increasing over time, resulting in an extensive use of fine-needle aspiration (FNA) and cytology. Tailored methods are required to improve the management of thyroid nodules, including algorithms and web-based tools. To assess the performance of the Thyroid Nodule App (TNAPP), a web-based, interactive algorithmic tool, in improving the management of thyroid nodules, we carried out a preliminary analysis on a cohort of outpatients. One h...

ea0037ep629 | Obesity and cardiovascular endocrinology | ECE2015

IGF-1 levels correlate with T3 status in chronic heart failure outpatients: preliminary data

Triggiani Vincenzo , Iacoviello Massimo , Leone Marta , Giagulli Vito Angelo , Guastamacchia Edoardo , Salzano Andrea , Bobbio Emanuele , Arcopinto Michele , Cittadini Antonio

Background: A variety of hormones may be down-regulated in CHF patients. Impaired activity of the GH/IGF-1 axis has been described and is associated with poor clinical status and outcome. Moreover, a decrease in serum T3 is correlated to the severity of the heart disease as assessed by the NYHA classification. Aim of this study was to evaluate a possible correlation between IGF-1 levels and T3 status in a cohort of CHF outpatients.M...

ea0090p61 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

The dual GIP/GLP-1 receptor co-agonist Tirzepatide vs GLP-1 receptor agonists as add-on to basal insulin in uncontrolled type 2 diabetes mellitus: A rapid review of randomized controlled trials and meta-analysis

Lisco Giuseppe , De Tullio Anna , Disoteo Olga , De Geronimo Vincenzo , Piazzolla Giuseppina , De Pergola Giovanni , Angelo Giagulli Vito , Jirillo Emilio , Guastamacchia Edoardo , Sabba Carlo , Triggiani Vincenzo

Tirzepatide, a once-weekly dual co-agonist of Glucose-Dependent Insulinotropic Polypeptide (GIP) and Glucagon-Like Peptide 1 (GLP-1) receptors, has been demonstrated to improve glucose control and reduced body weight in different therapeutic approaches. With this rapid review and meta-analysis, we systematically reviewed the efficacy and safety of injectable incretin-based therapy added to basal insulin compared to basal insulin plus background treatments titrated rigorously t...