Searchable abstracts of presentations at key conferences in endocrinology

ea0081p638 | Endocrine-Related Cancer | ECE2022

TKI related adverse events in patients with progressive and metastatic thyroid carcinoma: a retrospective analysis of our experience with cabozantinib during EXAM and EXAMINER clinical trial

Cappagli Virginia , Bottici Valeria , Viola David , Agate Laura , Molinaro Eleonora , Elisei Rossella

Background: Vandetanib and Cabozantinib are the only two multitarget tyrosine kinase inhibitors approved for the management of metastatic and progressive medullary thyroid cancer. (MTC) Despite their efficacy in terms of progression free survival prolongation and overall response rate, the drug-related toxicity is still a clinical problem, impairing patient’s quality of life and the compliance to the treatment. We retrospectively evaluate the adverse events (AEs) occurred...

ea0081p472 | Thyroid | ECE2022

Cervical lymph nodes metastases in differentiated thyroid cancer: impact on clinical outcome

Gambale Carla , Matrone Antonio , Contartese Lea , Prete Alessandro , Viola David , Agate Laura , Molinaro Eleonora , Elisei Rossella

Background: Cervical lymph node metastases at histology are common findings in differentiated thyroid cancer (DTC); however, their impact on clinical outcome is debated.Material and method: 1332 DTC patients, performed the first 131 I treatment between January 2010 and September 2012 and were divided into 2 groups: absence (Nx/N0) or presence (N1) of lymph node metastases at histology. The latter group was further split in central compartment ...

ea0014oc1.2 | Thyroid clinical | ECE2007

Expression gene profile may be useful for the diagnosis of thyroid malignancies

Piampiani Pamela , Romei Cristina , Cosci Barbara , Vivaldi Agnese , Ciampi Raffaele , Viola David , Bottici Valeria , Giannini Riccardo , Basolo Fulvio , Pinchera Aldo , Elisei Rossella

Although 20% of follicular neoplasms are papillary thyroid carcinoma (PTC), their cytological diagnosis is not diagnostic. A different profile of gene expression between malignant and benign thyroid tumors has been reported. Aim of this study was to identify a gene expression profile to be used in distinguishing malignant from benign thyroid neoplasms. By real-time RT-PCR we analyzed mRNA expression of 6 thyroid differentiation genes (TTF-1, PAX8, TPO, TSHr, NIS and Tg) and 5 ...

ea0014p365 | (1) | ECE2007

Usefulness of calcitonin (CT) measurement in wash-out fluid from fine needle aspiration biopsy in thyroid nodules of patients with dectectable serum CT

Renzini Giulia , Rago Teresa , Passannanti Paolo , Viola David , Cosci Barbara , Molinaro Eleonora , Grasso Lucia , Lucchetti Fabiana , Vitti Paolo , Pinchera Aldo , Elisei Rossella

Up to now there isn’t any study to validate the CT measurement in wash-out-fluid from FNAB in the diagnosis of medullary thyroid cancer (MTC). To demonstrate the usefulness of CT measurement in wash-out fluid from FNAB in thyroid nodules, we have retrospectively analyzed 25 cases with detectable serum CT in which CT measurement in wash-out-fluid from FNAB, citology and histological examination were available. In 7 cases CT level was <10 pg/ml: cytology was negative in...

ea0014p366 | (1) | ECE2007

Prognostic significance of BRAF mutation in patients affected by papillary thyroid carcinoma with a follow up of 20 years

Viola David , Romei Cristina , Biagini Agnese , Agate Laura , Molinaro Eleonora , Ciampi Raffaele , Renzini Giulia , Giannini Riccardo , Ugolini Clara , Berti Piero , Pinchera Aldo , Elisei Rossella

BRAFV600E is the most common mutation in papillary thyroid carcinoma (PTC). Anatomo-patology and clinical features of PTC with BRAFV600E are well described in literature.Aim of this study was to examine the prognostic significance of BRAFV600E in patients with PTC and a follow-up of 15-20 years.Genomic DNA was purified from 67 paraffin-embedded tumoral tissue. A PCR-SSCP analysis of exon 15 of BRAF ...