Searchable abstracts of presentations at key conferences in endocrinology

ea0070s8.3 | PCOS: from Genetics to Treatment | ECE2020

Current insights into the genetics of polycystic ovary syndrome

Visser JA

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder, affecting 10–18% of women of reproductive age. Based on the Rotterdam consensus, PCOS is diagnosed by at least two of the following three criteria: oligo- or anovulation, hyperandrogenism, and polycystic ovaries on ultrasound. Thus, four different phenotypes can be recognized. In addition, PCOS is also a metabolic disorder since many affected women present with obesity, insulin resistance and associa...

ea0008oc13 | Neuroendocrinology and Reproduction | SFE2004

Reduced expression of anti-Mullerian hormone (AMH) protein in the androgenised sheep ovary

Bull L , Stubbs S , Birch R , Robinson J , Themmen AP , Visser JA , Groome NP , Hardy K , Franks S

The prenatally androgenised sheep, like the Rhesus monkey, is an informative model for polycystic ovary syndrome (PCOS). We have recently demonstrated that AMH protein is reduced in preantral follicles of PCOS ovaries (Stubbs et al, Endocrine Abstracts 2004, 7 P186 ). We hypothesized that reduced expression of AMH is an effect of androgen excess. The aim of this study was to examine AMH immunostaining in ovaries from prenatally androgen-treated and control ewes. Ovaries were t...