Searchable abstracts of presentations at key conferences in endocrinology

ea0016p99 | Bone and calcium | ECE2008

Secondary osteoporosis in man with aromatase deficiency: positives and negatives of estrogen therapy

Pura Mikulas , Kottler Marie-Laure , Vanuga Peter , Carreau Serge , Vitesnik Karel , Mittre Herve

To date only seven cases of naturally occuring inactivating mutations of the aromatase gene in men have been documented. Osteoporosis is one of the typical signs of the aromatase deficiency in male patients. We report results of estrogen therapy in patient with formerly described frameshift mutation of the CYP19 gene, ins 1058 T. Bone mineral density (BMD) was assessed during three phases of estrogen therapy. Patient was substituted by calcium and vitamin D throughout t...