Searchable abstracts of presentations at key conferences in endocrinology

ea0067o41 | Oral Presentations | EYES2019

Clinical features of primary hyperparathyroidism in women of different age groups according to the Russian Online Register database

Mirnaya SS , Volodicheva VL , Bibik EE , Mokrysheva NG

Objective: The aim of the study was to compare the clinical features in three age-groups of women with primary hyperparathyroidism.Methods: The data about biochemical profile and disease complications in women with active stage of disease (n=645) was collected from the Russian Primary Hyperparathyroidism Registry. Group 1 included women 20–49 years old (n=215) unless the patients with suspected or confirmed multiple endocrine neopl...

ea0086p347 | Neuroendocrinology and Pituitary | SFEBES2022

Targeted Profiling of Endogenous Steroids in Mouse Plasma Using Liquid Chromatography-Mass Spectrometry Approach

Gazarkova Taťana , Plachka Kateřina , Kočova Vlčkova Hana , Novakova Lucie , Svec Frantisek

Stress is increasingly pervasive in modern society and an unavoidable stimulus to the human organism. Stressors, whether of social or physical type, activate the hypothalamic-pituitary-adrenal (HPA) axis, resulting in the upregulation of glucocorticoid levels and, in some cases, its de novo biosynthesis. Aside from HPA axis regulation, corticosteroids also modulate the immune response to inflammation and affect the whole-body metabolism. Accurate quantification of endogenous s...

ea0081ep1026 | Thyroid | ECE2022

Detection of rare variants in BRAF gene in thyroid nodules

Bendlova Bela , Sykorova Vlasta , Pekova Barbora , Vaclavikova Eliska , Moravcova Jitka , Mastnikova Karolina , Vlček Petr , Katra Rami , Kodetova Daniela , Lastuvka Petr , Bavor Petr , Drozenova Jana , Chovanec Martin , Vcelak Josef

Objectives: Papillary thyroid carcinoma (PTC) is the most frequent malignant endocrine disease and the most common genetic cause of the PTC is the substitution c.1799T>A (p.V600E) in the BRAF gene (35-70% of PTC) that represents more than 95% of BRAF mutations. Other rare mutations in the BRAF gene include other substitutions (e.g. p.K601E), small deletions or insertions close to codon 600. The aim was to analyze a large cohort of thyroid nodules...