Searchable abstracts of presentations at key conferences in endocrinology

ea0022p127 | Cardiovascular endocrinology and lipid metabolism | ECE2010

Subjects homozygous for the BCL1 polymorphism of glucocorticoid receptor gene may have an increased risk for impaired endothelial function

Stamatelopoulos Kimon , Saltiki Katerina , Mantzou Emily , Voidonikola Paraskevi , Papamichael Christos , Alevizaki Maria

Objectives: Glucocorticoids may affect cardiovascular risk. Polymorphisms in the glucocorticoid receptor (GlucR) gene have been associated with increased risk for cardiovascular disease. We investigated whether the common Bcl1 polymorphism of the GlucR gene (associated with increased sensitivity to glucocorticoids) may be associated with early markers of atherosclerosis.Methods: Two hundred and fourteen middle aged apparently healthy subjects (age &#8230...

ea0020p355 | Diabetes and Cardiovascular | ECE2009

Endogenous estrogen levels are associated with endothelial function in males independently of lipid levels

Saltiki Katerina , Stamatelopoulos Kimon , Voidonikola Paraskevi , Mantzou Emily , Papamichael Christos , Alevizaki Maria

Introduction-aim: It has been suggested that estrogen may play an important role in the regulation of endothelium-dependent vasodilatation in both sexes. Especially in men, estradiol administration has been shown to improve endothelial function; however such reports are conflicting. The aim of our study was to examine the relation of endogenous sex hormone levels with markers of early atherosclerosis in a cohort of apparently healthy individuals.Methods:...

ea0020p455 | Obesity and Metabolism | ECE2009

Thyroid function tests, measures of adiposity and metabolic syndrome in apparently healthy euthyroid individuals

Saltiki Katerina , Stamatelopoulos Kimon , Voidonikola Paraskevi , Mantzou Emily , Papamichael Christos , Alevizaki Maria

Objective: Thyroid function tests (TFTs) have been associated with obesity; however associations with the type of adiposity have not been examined. Ultrasound (U/S) was used to assess regional adiposity in euthyroid individuals. Associations of thyroid function with obesity parameters and presence of the metabolic syndrome (MS) were investigated.Methods: Of 302 apparently healthy slightly overweight individuals (age 42.9±8.8, BMI 19.0–43.3, med...

ea0014p234 | (1) | ECE2007

Association of sex hormone-binding globulin (shbg) levels with measures of adiposity and metabolic profile in apparently healthy individuals

Saltiki Katerina , Voidonikola Paraskevi , Stamatelopoulos Kimon , Mantzou Emily , Chryssohoou Eleftheria , Papamichael Christos , Alevizaki Maria

Objective: The association of SHBG levels with obesity, hyperinsulinemia and metabolic abnormalities is well recognized in both men and women. Recent data suggest that SHBG levels are an important predictor of cardiovascular disease (CVD) risk. Several methods have been used for the measurement of adiposity including ultrasonography (U/S) which is a reliable and low-cost method. We used U/S to assess regional adiposity and investigated possible associations with SHBG levels.</...

ea0016oc6.5 | Metabolism and cardiovascular | ECE2008

Association of the SHBG gene promoter polymorphism with early markers of atherosclerosis in apparently healthy women

Saltiki Katerina , Voidonikola Paraskevi , Lazaros Leandros , Stamatelopoulos Kimon , Mantzou Emily , Georgiou Ioannis , Anastasiou Eleni , Papamichael Christos , Alevizaki Maria

Objective: Androgen may be detrimental in the development of cardiovascular disease in women. We investigated possible associations between the (TAAAA)n polymorphism of sex hormone binding globulin (SHBG) gene promoter, which influences transcriptional efficiency of the SHBG gene and thus the tissue androgen availability and early markers of atherosclerosis in apparently healthy women.Design and methods: In this prospective clinical study, 153 con...