Endocrine Abstracts

Introduction: A relation between polycystic ovary syndrome (PCOS) and nonalcoholic fatty liver disease (NAFLD) was demonstrated recently. Both NAFLD and PCOS are associated with increased risk for type 2 diabetes and cardiovascular disease. NAFLD liver fat score (NAFLD-LFS) has been implicated as a non-invasive surrogate marker for NAFLD. The aim of this study was to identify the prevalence of NAFLD in different PCOS phenotypes using NAFLD-LFS.Methods: W...

Introduction: There is a link between polycystic ovary syndrome (PCOS) and nonalcoholic fatty liver disease (NAFLD). Here, we analyzed transaminazes and their relation to insulin resistance (IR) in PCOS women.Methods: We analyzed 600 women with PCOS diagnosed using ESHRE/ASRM criteria (age:25.6±5.9 years, BMI: 30.6±6.9 kg/m2), and 125 BMI-matched healthy controls (age: 31.4±5.3 years, BMI: 29.6±6.8 kg/m2). IR was...

Polycystic ovary syndrome (PCOS) is a complex reproductive disorder that is usually associated with metabolic disturbances such as obesity, dyslipidemia and insulin resistance. In this study, female rats treated with nonaromatizable 5α dihydrotestosterone (DHT) were used as an animal model of PCOS. The aim of this study was to assess the presence of inflammation in liver and visceral adipose tissue (VAT), which accompanies metabolic disturbances in animal model of PCOS. F...

Introduction: Women with polycystic ovary syndrome (PCOS) have numerous risk factors that lead to higher risk for cardiovascular diseases (CVD) and stroke. Measurement of carotid intima-media thickness (CIMT) is a marker of CVD.Methods: We analyzed 399 women with PCOS diagnosed using ESHRE/ASRM criteria (age: 25.5±5.1 years, BMI: 24.9±6.2 kg/m2), and 82 BMI-matched healthy controls (age 29.2±5.9 years, BMI 25.3±8.6 kg/m<sup...

Introduction: Polycystic ovarian syndrome (PCOS) is characterized by hyperandrogenism, chronic oligo-/anovulation and polycystic ovarian morphology. Hyperandrogenism is a key diagnostic feature of PCOS and according to ESHRE/ASRM criteria it can be clinical and/or biochemical. SPISE index (single-point insulin sensitivity estimator index) is a new indicator of insulin sensitivity and a predictor of abnormal glucose metabolism. The aim of the research was to analyse association...

Introduction: Metformin and oral contraceptive pills (OCP) are the most commonly prescribed medications among women with polycystic ovary syndrome (PCOS). The aim of this study was to compare effects of pill containing cyproterone-acetate (CPA) and metformin (METF) in women with PCOS during six months of follow-up.Methods: Group of 60 women with PCOS diagnosed by ESHRE/ASRM criteria were divided into 3 subgroups (20 women each), which were treated with d...

Introduction: Increased adrenal androgen production is present in 20–60% of women with polycistic ovary syndrome (PCOS). Possible mechanism is not clarified yet and could be related to altered hypothalamic-pituitary-adrenal-axis (HPA) activity or a consequence of adrencortical steroidogenic abnormalities. The aim of the study was to assess HPA sensitivity in PCOS women using different doses of dexamethasone.Methods: We analyzed 359 women with PCOS d...

Introduction: Recently, it was suggested that insulin resistance index using C-peptide (CIR) could be a better marker of insulin resistance than homeostasis model assessment (HOMA-IR) in patients with type 2 diabetes mellitus. The aim of this study was to investigate performance of CIR index in PCOS subjects.Methods: We evaluated 187 PCOS women (PCOS: 25.38±6.32 kg/m2; 26.01±5.16 years) diagnosed using ESHRE/ASRM criteria and 42 heal...

Introduction: It has been shown that subjects with normal fasting glucose (NFG) and normal glucose tolerance (NGT), whose plasma glucose concentration does not return to their fasting plasma glucose (FPG) level within 2 h following standard oral glucose tolerance test (OGTT), have higher risk of progression into type 2 diabetes (T2D) than NFG/NGT subjects whose glucose returns to FPG level after OGTT. Although the development of T2D during the life of woman with polycystic ova...

Introduction: Polycystic ovary syndrome (PCOS) phenotypes A and B are considered to be more hyperandrogenic in comparison to phenotypes C and D that are considered to be mostly reproductive. The aim of this study was to analyze distribution of androgens in different phenotypes in our PCOS population.Methods: We evaluated 365 PCOS women (PCOS:25.05±6.24 kg/m2; 25.48±5.21 years) diagnosed using ESHRE/ASRM criteria and 125 healthy women...