Endocrine Abstracts

Introduction: Resistant thyrotoxicosis is condition in which patients fail to respond to maximal doses of antithyroid drugs. Definitive treatment is radioactive ablation and operative treatment. However, achievement of euthyroid status before definitive treatment is important in patients with underlying cardiovascular disorder in whom thyroid crises can be detrimental.Case report: We describe a case of resistant thyrotoxicosis and right heart failure. A ...

McCune–Albright syndrome (MAS) is characterized by fibrous dysplasia (FD), cutaneous cafe-au-lait pigmentation and autonomous hyper-secretory endocrinopathies. Association of acromegaly with MAS is very rare. We present a case of a 35-year-old men with MAS, diagnosed with poly-ostotic fibrous dysplasia at the age of 12, no history of premature puberty, with GH secreting cystic macroadenoma 40×35×45 mm big and clinical picture of acromegaly, hypopituitarism and b...

We describe a case of cystic pheochromocytoma (PCC) with negative biochemical evaluation, diagnosed on the basis of hypertensive crises during operative management and histopathologic findings. A 57-year-old woman complained of several episodes of stabbing right upper abdominal pain accompanied by tachycardia, headache, lack of breath, elevated blood pressure and vomiting in the preceding three years. At presentation, blood investigations were significant only for mildly eleva...

The protein isoformes that are products of the Apolipoprotein E (APOB) gene polymorphism have partially altered biological activity and that may lead to greater susceptibility of the patientsto microvascular complications including Diabetic nephropathy (DN)in patients with the Type 2 diabetes mellitus (T2DM). The aim of this study was to evaluate the association between the allele ε2, ε3, and ε4 of the APOE gene, as well as their combination, w...

Background: Treatment of subclinical hypothyroidism (ScH) when TSH is between the upper reference value and 7mU/L, especially in patients younger than 65 years is controversial.Objectives: To compare the risk factors for atherosclerosis and echocardiographic parameters in patients with ScH1 (4, 2≤TSH≤7mU/L) to euthyroid subjects and patients with ScH2 (TSH>7mU/L).Material and Methods: Prospectively 54 consecutive pa...

Aims: Identifying the left ventricular systolic disfunction in obesity is crucial, due to its ability to predict cardiovascular morbidity. LV systolic function is traditionally assessed with the volumetric parameter LV ejection fraction (LVEF). However, normal values for LVEF in all categories of obesity are published in the literature. Furthermore, guidelines for the biomarkers of heart failure, NT-proBNP and BNP, in the obese population remain unclear. Given the restricted B...