Searchable abstracts of presentations at key conferences in endocrinology

ea0056gp254 | Thyroid non cancer | ECE2018

Proteome analysis of 3,5-T2-treated primary mouse hepatocytes

Golchert Janine , Lietzow Julika , Volker Uwe , Homuth Georg , Kohrle Josef

Introduction: Besides the classical thyroid hormones T4 and T3 the endogenous thyroid hormone metabolite 3,5-diiodothyronine (3,5-T2) attracted attention during the last years due to its metabolic activity. 3,5-T2 exerts thyromimetic action on the hypothalamus-pituitary-thyroid axis and the heart as well as on energy and lipid metabolism. In previous liver transcriptome analyses of 3,5-T2-treated lean and diet-induced obese male mice, effects on hepatic lipid, steroid, xenobio...

ea0032p183 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2013

Mendelian randomization suggests non-causal associations of testosterone with cardiometabolic risk factors and mortality

Haring Robin , Teumer Alexander , Volker Uwe , Dorr Marcus , Nauck Matthias , Biffar Reiner , Volzke Henry , Baumeister Sebastian , Wallaschofski Henri

Background: Prospective studies showed that low serum testosterone concentrations are associated with various cardiometabolic risk factors and mortality. But the causal nature of these associations is controversial.Methods: We studied 1882 men aged 20–79 years with serum testosterone concentrations and genotyping data from the longitudinal population-based Study of Health in Pomerania.Testosterone concentrations were cross-sec...

ea0041oc4.2 | Thyroid - Clinical | ECE2016

Molecular fingerprint of experimental thyrotoxicosis on human metabolism: combined metabolome and proteome study

Pietzner Maik , Engelmann Beatrice , Kacprowski Tim , Golchert Janine , Dirk Anna-Luise , Homuth Georg , Hammer Elke , Nauck Matthias , Wallaschofski Henri , Munte Thomas , Friedrich Nele , Volker Uwe , Brabant Georg

The functional state of the thyroid is usually determined by thyrotropin (TSH), whose serum levels depend on circulating thyroid hormone (TH) levels. This feedback mechanism is tightly controlled in the individual and contrasts broad reference range for TSH in the general population, leading to the concept of subclinical thyroid disease. We studied a model of experimental thyrotoxicosis in humans employing an untargeted metabolome and proteome approach. This allowed us to gain...

ea0056gp253 | Thyroid non cancer | ECE2018

Identification of new thyroid hormone dependent biomarkers for a successful replacement therapy

Nock Sebastian , Johann Kornelia , Harder Lisbeth , Hofig Carolin S , Kracke Vanessa , Engelmann Beatrice , Homuth Georg , Volker Uwe , Mittag Jens , Brabant Georg

Thyroid hormones (TH) play a pivotal role in embryonal and postnatal development in vertebrates, hence, their secretion is highly regulated. In clinical practice TSH and free T4 (fT4) are commonly used as the most reliable parameters to evaluate the TH status. But they only represent the TH receptor β driven status of the hypothalamic-pituitary-thyroid axis while organ or tissue specific TH availability may be different. This discrepancy originates in the tissue specific ...

ea0056p1040 | Thyroid (non-cancer) | ECE2018

A thyroid hormone-independent molecular fingerprint of 3,5-diiodothyronine suggests a strong relation with coffee metabolism in humans

Pietzner Maik , Homuth Georg , Kohrle Josef , Budde Kathrin , Kastenmuller Gabi , Brabant Georg , Volzke Henry , Artati Anna , Adamski Jerzy , Volker Uwe , Nauck Matthias , Friedrich Nele

Background: Numerous animal models have shown impressive beneficial metabolic effects of the putative thyroid hormone (TH)-derivative 3,5-diiodothyronine (3,5-T2), including the prevention of insulin resistance or the reversal of hepatic steatosis, in the absence of thyrotoxic side effects. In contrast, the endogenous fate of 3,5-T2 in humans is still unclear. Comprehensive molecular profiling holds promise to gain deeper insights in metabolic alterations associated with serum...

ea0084op-08-37 | Oral Session 8: Basic 2 | ETA2022

Resistance to thyroid hormone alpha: molecular, biochemical and physiological approach to diagnosis and therapy

Agostini Maura , Pietzner Maik , Marelli Federica , Prapa Matina , Moran Carla , Edward Visser W. , Brown Dave , Thomas Ellen , Schoenmakers Erik , Romartinez-Alonso Beatriz , Scheuplein Rabea , Tylki-Szymanska Anna , Lyons Greta , Watson Laura , Rajanayagam Odelia , Schwedhelm Edzard , F. Hartmann Michaela , Wudy Stefan , Probst Maiken , MacDonald Stephen , Thomas William , Arlt Wiebke , Volker Uwe , M. Main Katharina , Feldt-Rasmussen Ulla , T. Dattani Mehul , Koren Dahll Louise , Demir Korcan , Kara Cengiz , Kirbiyik Ozgur , Mammadova Jamala , Cayır Atilla , Yarali Oguzhan , Phan-Hug Franziska , Sakremath Rajesh , Mohamed Zainaba , Shinawi Marwan , Gill Harpreet , pacaud Daniele , Perrier Renee , Poke Gemma , Hunter Wendy , Douzgou Sofia , Wakeling Emma , Gardham Alice , Lim Derek , Shears Deborah , Freel Marie , Omladic Jasna , Tansek Mojca , Writzl Karin , Farooqi Sadaf , Kopp Peter , Schwabe John , Persani Luca , Chatterjee Krishna

Objectives: THRA mutations cause Resistance to Thyroid Hormone α (RTHα), an underdiagnosed disorder with hypothyroid features but near-normal thyroid function tests (TFTs). We developed a pathway, combining molecular analyses, new biomarkers and physiological measurements, to better diagnose and treat this disorder.Methods: Structural and functional analyses of THRA variants, discovered by next generation sequencing in specifi...