Endocrine Abstracts

Introduction: Non-functioning pituitary adenomas, usually macroadenomas, represent around 30% of pituitary tumors. Patients often present with signs of mass effect and symptoms of pituitary insufficiency. We report a complicated case of a cystic pituitary ‘macroadenoma’ presenting with recurrent mucocoeles likely due to underlying sinusitis.Case report: A 42-year-old Caucasian female presented with chronic headaches and unilateral temporal visu...

A 60 year old pest control worker presented to the dermatologists with a 3-month history of progressive thickening and change in texture of skin lesions affecting the face, lips and eyelids. Histology revealed papular mucinosis/lichen myxoedematosus and he was treated with plasma exchange, high dose steroids and cyclophosphamide. Investigations for associated tiredness, four months following presentation and initiation of therapy revealed impaired GH and cortisol responses to ...

Patients with histology confirmed acromegaly who have undergone trans-sphenoidal surgery and radiotherapy often have active acromegaly despite no evidence of adenoma on MRI. Currently 111In Octreotide, a radioactive tracer, is used in the assessment of neuroendocrine tumours, with 70-90 percent sensitivity for detection. Studies to date however have not looked at 111In Octreotide as an alternative measure to assess patients who present with biochemically active acromegaly desp...

Back ground: Acute adrenal insufficiency is a life threatening condition with multiple aetiologies. The adrenal gland is susceptible to thrombosis and hemorrhagic infarction due to rich arterial supply and limited venous drainage. We present a case report of a simultaneously detected acute adrenal insufficiency due to bilateral adrenal haemorrhagic infarcts with ischemic bowel as the first manifestation of antiphospholipid syndrome (APS).Case history: A ...

TESTOSTERONE-REPLACEMENT STIMULATED HYPERPROLACTINAEMIAR Sodi, R Fikri, M Diver, L Ranganath & J Vora*.Departments of Clinical Chemistry and Endocrinology*Royal Liverpool and Broadgreen University Hospital,Liverpool, UK. L7 8XP.Around half of all men with macroprolactinomas have hypogonadism and may require exogenous testosterone replacement. However, testoste...

Lymphocytic adenohypophysitis (LA) is a rare inflammatory disorder of the pituitary, probably auto-immune in origin, usually affecting young pregnant women. Clinical features resemble a pituitary adenoma but differing in the hierarchy of endocrine loss, preferentially destroying ACTH and TSH secreting cells. A useful diagnostic feature is pituitary enhancement with gadolinium on MRI.A 39-year old female, with treated hypothyroidism, was referred to endocrinology out-patien...

PTH plays an important role in bone metabolism. Active acromegaly is associated with increased bone turnover. Reduction in bone turnover markers occurs following biochemical cure/control of acromegaly. We examined the effect of active acromegaly and its treatment on PTH concentration and PTH target-organ sensitivity.10 patients with active acromegaly (defined as GH nadir greater than 1mU/L following 75g oral glucose load and IGF1 above reference range) a...

Adult Growth Hormone Deficiency (AGHD) is associated with relative phosphate deficiency. Phosphate is an important determinant of serum PTH concentration. PTH target-organ sensitivity is reduced in AGHD and may underlie the pathogenesis of AGHD-related osteopaenia. We examined the effect of phosphate supplementation on change in PTH target-organ sensitivity when given simultaneously with Growth Hormone Replacement (GHR) in AGHD patients.24 AGHD patients ...

Background: Untreated adult growth hormone deficiency (AGHD) is associated with hypertension, obesity and hyperleptinemia. Leptin is linked to obesity related hypertension, is secreted in a circadian rhythm and may contribute to the regulation of BP circadian rhythmicity.Methods: We studied the relationship between plasma leptin (half hourly samples), ambulatory systolic BP (SBP), diastolic BP (DBP) and mean arterial pressure (MAP) over a 24-h period in ...

Leptin stimulates osteoblastic cell proliferation, differentiation and mineralisation and inhibits osteoclast generation; leptin secretion and bone turnover are altered in adult growth hormone deficiency, a condition associated with osteoporosis. The aim of this study was to investigate leptin circadian rhythm and its association with bone turnover in untreated AGHD and following growth hormone replacement (GHR).We sampled peripheral venous blood at half...