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ea0022s21.3 | The cardiometabolic interface | ECE2010

Mechanisms and treatment of diabetic dyslipidemia

Vrablik Michal

Type 2 diabetes and insulin resistance are associated with a complex change of metabolism of plasma lipoproteins that conveys a substantial part of increased cardiovascular (CV) risk of the diabetics. While quantity of lipoprotein particles (lipid concentrations) remain close to normal, their quality (composition) changes markedly. Lipoprotein metabolism in type 2 diabetes differs from normal at three levels. First, the production of very low-density lipoproteins (VLDLs) in th...