Endocrine Abstracts

Interleukin-6 (IL-6) has been shown to be involved in the pathogenesis of several bone diseases characterized by an imbalance between bone resorption and formation. Lately we have published our data suggesting an important role of IL-6 in thyrotoxicosis-related osteoporosis in mice (Horm Metab Res 2007 39 1–5).Aim: The aim of the study was to estimate serum markers of bone turnover: osteoclast-derived tartrate-resistant acid phosphatas...

Interleukin-6 (IL-6) has been shown to be involved in the pathogenesis of several bone diseases characterized by a negative balance between bone resorption and formation.The aim of the study was to estimate serum markers of bone turnover: osteoclast-derived tartrate-resistant acid phosphatase form 5a (TRACP 5b) and osteocalcin in IL-6 knock-out mice to assess the role of IL-6 in the pathogenesis of thyrotoxicosis-related disturbances of bone metabolism.<...

Herniation of the subarachnoid space into the sella turcica results in empty or partially empty sella syndrome. Primary sella turcica syndrome is idiopathic, whereas secondary empty sella is a result of central nervous system pathologies, which may manifest as visual disorders, due to optic chiasm compression or displacement. The purpose of this study was to determine whether empty and partially empty sella—either primary or secondary—are risk factors for optic chias...

Background: Ehlers–Danlos syndrome is a group of genetic conditions characterized by alterations in connective tissue structure, which produces various symptoms. Some subtypes of this syndrome are associated with structural alterations of tenascin-X, an extracellular matrix glycoprotein encoded by the TNXB gene, which partially overlaps the CYP21A2 gene, which encodes adrenal 21-hydroxylase. The purpose of this study was to assess the relationship between tenascin-X level...