Searchable abstracts of presentations at key conferences in endocrinology

ea0024p37 | (1) | BSPED2010

Type 2 diabetes in childhood: building a platform for interventions to prevent the progression to cardiovascular disease

Barnett A , Barrett T , Cotter C , Dunger D , Fulton E , Heywood J , Ilsley E , O'Brien A , Shield J , Wales J

Type 2 diabetes (T2DM) is increasing in children in the UK and worldwide, most likely related to the rising prevalence of obesity. We are developing a UK national cohort of children (under 18 completed years) with diabetes defined by WHO criteria, suspected type 2, BMI above 85th centile; but who do not have genetically confirmed monogenic diabetes, secondary diabetes, or any evidence of pancreatic autoimmunity. The aim of this study is to describe the characteristics of the f...

ea0003p164 | Growth and Development | BES2002

Monitoring insulin-like growth factor-I and IGF binding protein-3 in children and adolescents on GH treatment using filter paper blood spots

Das U , Price D , Khosravi J , Wales J , Butler G , Kibirige M , Diamandi A , Jones J , Hall C , Clayton P

In childhood an appropriate response to GH treatment is achieved by titration of growth response against dose administered, with careful observation for side-effects. In order to evaluate the potential use of IGF monitoring in children treated with GH, a cross-sectional study has been carried in 215 children and adolescents (134 with GH deficiency, 54 with Turner syndrome and 29 with non-GHD growth disorders) treated with GH for 0.2 to 13.7 years.IGF-I ...

ea0019oc27 | Bone and Calcium | SFEBES2009

Adipokines may modify osteoblast wnt-signalling through dickkopf-1, and promote osteoclastogenesis by altering RANK-L and osteoprotegerin signalling in obese children

Dimitri P , Wales J , Bishop N

Introduction: We have recently presented data demonstrating total body and regional bone mass relative to body size is reduced in obese children. Adipokines have been shown to play a role in bone metabolism. We hypothesised that 1) increased bone turnover would be associated with reduced bone mass 2) increased serum leptin would be associated with increased osteoclastogenic factors 3) reduced adiponectin woul...

ea0017oc4 | Endocrinology 1 | BSPED2008

Childhood obesity limits gain in total body and lumbar bone size and radial bone mass. A longitudinal study

Dimitri P , Wales J , Bishop N

We have previously shown that obese children with prior fracture have a lower bone mass for body size. We further hypothesised that obese children would fail to gain bone mass in relation to body size over a one-year period compared to lean controls.Methodology: Out of 103 children recruited into obese (BMI>98th percentile) and control (BMI<98th percentile) groups at baseline, 66 children aged 6.5–18 years returned at one year. Total body an...

ea0027p28 | (1) | BSPED2011

Prophylactic thyroidectomy in children with MEN2 in the United Kingdom

Prete Francesco Paolo , Morkane Clare , Watkinson J , Shaw N , Alvi S , Squire R , Harrison B , Wales J , Clayton P , Morrison P , Carson D , Brain C , Hindmarsh P , Dattani M , Spoudeas H , Buchanan C , Albanese A , Amin R , Piero A , Kurzawinski T

Introduction: Timing, extent, complications rate and long term results of paediatric prophylactic thyroidectomy (pPT) for MEN2 in the UK are unknown.Methods: All UK centers performing pPT were invited to participate in the study.Data were obtained from notes and hospitals electronic databases.Results: Fifty-one children (27 males) were included.All had genetic test at the mean age of 5 years (median 3, range 0.25–15), confirmi...