Searchable abstracts of presentations at key conferences in endocrinology

ea0020p62 | Thyroid | ECE2009

Soluble CD40 and its ligand CD154 in patients with Graves’ orbitopathy during combined therapy with corticosteroids and teleradiotherapy

Mysliwiec Janusz , Waligorski Dariusz , Nikolajuk Agnieszka , Gorska Maria

It was shown recently that orbital fibroblasts express intensively CD40 and its ligation stimulates proinflammatory cytokines, glicosoaminoglycans and PGE2 production. CD40/CD154 interaction in the pathogenesis of Graves’ orbitopathy (GO) is suggested an important pathway of T cells induced fibroblast activation and proliferation.Aim: To assess the role of CD40/CD154 interaction in GO pathogenesis and to estimate usefulness of soluble CD4...

ea0037oc6.4 | Thyroid | ECE2015

The usefulness of determining the presence of BRAF (V600E) mutation in fine needle aspiration cytology of thyroid nodules cells

Kowalska Aldona , Kopczynski Janusz , Kowalik Artur , Gasior-Perczak Danuta , Palyga Iwona , Lizis-Kolus Katarzyna , Waligorski Dariusz , Szyska-Skrobot Dorta , Walczyk Agnieszka , Hurej Stefan , Chil Agnieszka , Chodurska Renata , Chlopek Malgorzata , Wypiorkiewicz Elzbieta , Nowak Ewelina , Gozdz Stanislaw

Introduction: Fine needle aspiration cytology (FNACC) is the basic tool used in the diagnosis of thyroid cancer (TC) in nodular goitre. FNACC does not allow for the establishment of a clear diagnosis in 15–30% of cases (mainly follicular lesions). Molecular biology techniques can be useful, allowing for the detection, in FNACC smears, of the known mutations involved in the oncogenesis.Aim: To evaluate the usefulness of the detection of the BRAF muta...