Searchable abstracts of presentations at key conferences in endocrinology

ea0019p327 | Steroids | SFEBES2009

Measuring cortisone production in man using a new stable isotope tracer

Hughes K A , Reynolds R M , Andrew R , Walker B R

Background: 11β-hydroxysteroid dehydrogenases (11β-HSD1&2) interconvert cortisol (F) and cortisone (E). Although 11β-HSD1 reductase activity has been measured in vivo, E production (dehydrogenase activity) has not been quantified using a Gold Standard technique, steady state tracer infusion.Aim: To develop a method to measure E production in vivo using the stable isotope tracer d2-cortisone (d2E).Me...

ea0021cm3.3 | Management of congenital adrenal hyperplasia across the lifespan | SFEBES2009

The adult with CAH: results of the UK congenital adrenal hyperplasia, adult study executive (CaHASE)

Ross R J , Willis D S , Wild S H , Krone N , Doherty E J , Han T S , Carroll P V , Conway G S , Rees D A , Stimson R H , Walker B R , Connell J C , Arlt W

Background: No treatment guidelines exist for CAH adults. To address this we have undertaken a cross-sectional analysis of health status.Patients and methods: Three hundred and eighty patients from 17 tertiary centres were contacted: 203 (53%) consented (138 f, 65 m, median age 34 (range 18–69) years). One hundred and sixty-five had classic and 34 non-classic CAH. The UK prevalence is 3591 adults >18 years therefore the capture rate was 5.7%. Re...