Searchable abstracts of presentations at key conferences in endocrinology

ea0077op2.4 | Adrenal and Cardiovascular | SFEBES2021

Modelling changes in the control, secretion and metabolism of cortisol during and after heart surgery

Galvis Daniel , Zavala Eder , Walker Jamie , Upton Thomas , Lightman Stafford , Angelini Gianni , Gibbison Ben

Control mechanisms of adrenocorticotrophic hormone (ACTH) and cortisol (CORT) secretion and metabolism during acute systemic inflammation (e.g. major surgery) have never been clearly elucidated. We sampled blood every 10 minutes for 12 h during and after coronary artery bypass grafting (CABG) in 10 patients to create profiles of ACTH, CORT and inflammatory mediators and compared these to healthy controls. PatientsÂ’ ACTH and CORT responses were classified into one of three...