Searchable abstracts of presentations at key conferences in endocrinology

ea0002sp15 | Maternal and Fetal Responses to Environmental Challenges of Feto-Placental Function | SFE2001


Wallace J

Human adolescent pregnancy is characterised by poor pregnancy outcome; the risks of spontaneous miscarriage, prematurity and low birth-weight are particularly acute in girls who are still growing at the time of conception. Studies using an adolescent sheep paradigm demonstrate that in growing females who are overnourished throughout pregnancy, growth of the placenta is impaired resulting in a major decrease in lamb birth-weight relative to adolescent dams receiving a moderate ...

ea0037s20.1 | Endocrine consequences of childhood cancer treatment | ECE2015

Reproductive function in cancer survivors

Wallace W Hamish

With increasing numbers of survivors from cancer at a young age the issue of fertility preservation has assumed greater importance. Female fertility preservation provides significantly different challenges to that for the male. Embryo freezing is now an accepted and well-established procedure in many centres, but is not available for children who do not have a partner. Cryopreservation using vitrification of mature oocytes has become increasingly successful, but requires the p...

ea0012p104 | Reproduction | SFE2006

Population reference ranges for plasma testosterone and calculated free testosterone in older men

Teoh YP , Wallace AM

ObjectiveTo establish a set of population derived reference ranges for plasma total testosterone, sex hormone binding globulin (SHBG) and calculated free testosterone (FT) values especially in older men.BackgroundThe age-related decline in testosterone concentrations in men is gradual and both cross-sectional and longitudinal data have shown that there was a small but significant decline in total and free tes...

ea0003p260 | Steroids | BES2002

Assessment of mineralocorticoid status by urinary corticosteroid profiling using gas chromatography-mass spectrometry (GCMS)

Shakerdi L , Fraser R , Wallace A

Corticosteroids are major contributors to normal blood pressure control and to hypertension. The diagnosis of 'primary aldosteronism' based on raised aldosterone: renin ratios is now common although demonstration of an adrenocortical tumour remains rare. Moreover, the relationship between aldosterone and renin or angiotensin II in essential hypertension is often disturbed, suggestive of altered control of aldosterone biosynthesis. Aldosterone is synthesised from 11-deoxycortic...

ea0085p93 | Thyroid | BSPED2022

Thyroid hormone resistance from misdiagnosis to successful pregnancy

Heffernan Emmeline , Wallace Helen , Graham Una

Thyroid hormone resistance is a rare condition, caused by mutations of the thyroid hormone receptor beta (THRB) gene, inherited in an autosomal dominant manner, resulting in decreased tissue sensitivity to thyroid hormone action, leading to high FT4 levels with normal TSH levels. We present a case of thyroid hormone resistance, initially misdiagnosed and treated as hyperthyroidism. An 8 year old girl was referred due to poor appetite, FT4 level was elevated (38.5 pmol/l) with ...

ea0028p146 | Neoplasia, cancer and late effects | SFEBES2012

Physiological levels of soy isoflavones inhibit the growth of oestrogen receptor β-positive but not α-positive breast cancer cells

Wallace Joanne , Gow Iain , Warnock Mary

The biphasic effect of soy isoflavones (genistein and daidzein) on oestrogen receptor (ER)α+ breast cancer cell proliferation is well documented, with concentrations of ≤10 µM promoting proliferation, and growth inhibitory and apoptotic effects seen at concentrations ≥10 µM. However genistein concentrations as low as 1nM may inhibit the proliferation of some ERα-/β+ cells. This is at odds with epidemiological evidence ...

ea0013s12 | Transdifferentiation in the endocrine system | SFEBES2007

Pancreatic trans-differentiation and the treatment of liver damage

Wallace Karen , Marek Carylyn , Wright Matthew

The liver performs essential functions including the control of blood nutrient levels; the synthesis of many blood proteins; the metabolism of bile components and the conversion of ammonia to urea for excretion by the kidney. Impaired urea synthesis is often the cause of coma and death in patients with liver failure. The only treatment for liver failure at present is transplantation.Stem cells may be a promising future resource for the treatment of acute...

ea0013p117 | Comparative | SFEBES2007

Performance characteristics of an intact PTH recently developed for the Abbott Architect immunoassay analyser

Smith Karen , Wallace Mike , Louden Ian

Concerns on the noncomparibility of intact parathyroid hormone (iPTH) methods have recently been voiced (Cantor T et al; Clin Chem 2006, 52, 1771–6). It is therefore important that any new iPTH immunoassays are thoroughly validated before routine use. We describe performance characteristics for an iPTH immunoassay on the ARCHITECT 8200i analyser as compared with iPTH measurement on the Diasorin LIAISON platform. Potassium EDTA plasma samples (n=80) we...

ea0009p145 | Steroids | BES2005

The aldosterone/renin ratio using renin concentration compared to renin activity in a healthy population

Al-Hashmi K , Wallace A , Connell J

Background: An elevated plasma aldosterone to renin ratio (ARR) is widely accepted as being important for the detection of primary hyperaldosteronism. The ability to measure renin at extremely low concentrations is the most critical factor in determining the diagnostic reliability of the ARR. We carried out this study to establish a reference interval for the ARR as part of an evaluation of a new automated platform for the simultaneous measurement of aldosterone (PAC) and dire...

ea0007p139 | Growth and development | BES2004

Transdermal testosterone application: pharmacokinetics and effects on pubertal status, short-term growth and bone turnover

Ahmed S , Mayo A , Macintyre H , Wallace A

Aim - To assess the effect of transdermal testosterone (TT) on free testosterone concentrations in saliva and on short-term growth and bone turnover in boys with growth or pubertal delay.Method - Prospective, randomized, cross-over study over 26 weeks with 4 weeks of Run-In, 8 weeks of Treatment I (8 hours/12 hours), 4 weeks of Wash-Out, 8 weeks of Treatment II (8 hours/12 hours) and 4 weeks of final Wash-Out.Main Outcome Measures ...