Searchable abstracts of presentations at key conferences in endocrinology

ea0016p152 | Clinical cases | ECE2008

Pituitary carcinoma presenting as Cushing's disease

Spilcke-Liss Elisabeth , Wallaschofski Henri

At our department of Endocrinology a 44-year-old patient with typical clinical signs of Cushing’s disease presented. Diagnostic procedure showed an ACTH-producing adenoma of the pituitary gland, so the patient underwent transsphenoidal surgery. Afterwards, hypercortisolism persisted and was treated with Ketoconazole. After a short period of time a pituitary hemorrhage occurred and resulted not only in a complete remission of Cushing’s symptoms, but also in hypopituit...

ea0022p355 | Diabetes | ECE2010

Prediction of incident diabetes mellitus by baseline insulin-like growth factor 1 levels

Schneider Harald , Wallaschofski Henri , Stalla Gunter-Karl , Wittchen Hans Ulrich

Objective: Insulin-like growth factor 1 (IGF1) is associated with metabolic parameters and involved in glucose metabolism. Low IGF1 has been implicated in the etiology of glucose intolerance. However, epidemiological data are scarce and the role of IGF1 in prospective studies is not clear to date.Research design and methods: We measured IGF1 levels in 7665 subjects free of diabetes from two German prospective cohort studies, the DETECT study and SHIP and...

ea0020oc3.4 | Reproduction/Stress/Endocrine Disruptors | ECE2009

Reference ranges for sex hormone-binding globulin and free testosterone index in adult men

Friedrich Nele , Volzke Henry , Krebs Alexander , Nauck Matthias , Wallaschofski Henri

Objective: The majority of circulating testosterone is bound to sex hormone-binding globulin (SHBG), but also to albumin and cortisol-binding globulin. The remaining part is free-circulating testosterone unattached to serum proteins, which represents the active form of the hormone. A common measurement of the free testosterone is the calculated free testosterone index (FTI)=100*(total testosterone/SHBG). Testosterone is the principal male sex hormone and is involved in the reg...

ea0011p885 | Thyroid | ECE2006

Is subclinical hyperthyroidism associated with blood pressure and hypertension?

Völzke Henry , Dörr Marcus , Wallaschofski Henri

Objectives: While evidence for an increased risk of hypertension in both overt hyperthyroidism and overt hypothyroidism is consistent, the relation between subclinical hyperthyroidism and blood pressure has not yet received sufficient attention. We aimed to investigate possible associations of decreased serum thyrotropin levels and subclinical hyperthyroidism with blood pressure, pulse pressure, and the risk of hypertension.Design: The population-based c...

ea0022p730 | Steroid metabolism & action | ECE2010

Prospective association of low total testosterone levels with adverse lipid profile and incident dyslipidemia: results from the study of health in Pomerania

Haring Robin , Baumeister Sebastian , Volzke Henry , Dorr Marcus , Felix Stephan , Kroemer Heyo , Nauck Matthias , Wallaschofski Henri

Context: Previous studies suggest that total testosterone levels influences lipid metabolism. It has not been investigated whether these levels are prospectively associated with an unfavourable lipid profile including increased risk of incident dyslipidemia.Design and setting: We used data of 1468 men aged 20–79 years, repeatedly examined in the population-based Study of Health in Pomerania. Serum total testosterone levels, measured by chemiluminesc...

ea0016p38 | Adrenal | ECE2008

Retrospective clinical data on more than 160 pheochromocytoma in three east german endocrine centers

Kopetschke Robert , Kilisli Aylin , Tuschy U , Wallaschofski Henri , Oelkers Wolfgang , Ventz Manfred , Quinkler Marcus

Objective: Pheochromocytoma is a rare disease with an incidence of 2–6 per million, and a prevalence of 0.1–0.6% in patients with hypertension. Pheochromocytoma may occur sporadically or as part of hereditary syndrome. According to the latest studies, among patients with non-syndromic pheochromocytoma, up to 24% of tumors may be inherited. However, genetic testing was not generally performed until recently. There is still a debate which pheochromocytoma patient shoul...

ea0016p349 | Growth and development | ECE2008

Population-based data of quality of life assessment of growth hormone deficiency in adults (QoL-AGHDA)

Moock Joern , Albrecht Christin , Voelzke Henry , Nauck Matthias , Koltowska-Haggstrom Maria , Kohlmann Thomas , Wallaschofski Henri

Objective: Age- and gender-specific reference values for quality of life (QoL) measures are important to assess the impact of growth hormone deficiency (GHD). The objective of this study was to develop population-based data for the QoL-AGHDA instrument for Germany and to compare this data with corresponding Qol-AGHDA scores of the German KIMS cohort during growth hormone treatment, to investigate the association between the Qol-AGHDA score and the IGF-1 values in the German KI...

ea0016p370 | Growth factors | ECE2008

Associations of anthropometric parameters with serum IGF-1, TSH, prolactin and testosterone levels

Friedrich Nele , Steveling Antje , Nauck Matthias , Brabant Georg , Volzke Henry , Wallaschofski Henri

Background: Obesity is a major risk factor for the development of chronic diseases and a determinant of cardiovascular disease. Divergent associations between obesity and hormonal changes have been reported. The objective of the present study was to analyse the associations between different anthropometric measurements and serum hormone levels including insulin-like growth factor 1 (IGF-1), thyroid-stimulation hormone (TSH), prolactin, and testosterone.M...

ea0016p372 | Growth factors | ECE2008

Acromegaly is associated with high plasma fibrinogen and C reactive protein values after normalization of growth hormone and IGF-1

Friedrich Nele , Nonnenberg Dennis , Spilcke-Liss Elisabeth , Volzke Henry , Dorr Marcus , Wallaschofski Henri

Background: Acromegaly is associated with increased morbidity and mortality from cardiovascular disease. Several studies indicate that reduction of growth hormone (GH) to <1 μg/l or normalization of serum IGF-I reduces mortality to expected levels. Inflammatory markers, such as C-reactive protein (CRP) or haemostatic markers, such as fibrinogen have emerged as important cardiovascular risk markers in the general population.Objective and design: ...

ea0032p183 | Cardiovascular Endocrinology &amp; Lipid Metabolism | ECE2013

Mendelian randomization suggests non-causal associations of testosterone with cardiometabolic risk factors and mortality

Haring Robin , Teumer Alexander , Volker Uwe , Dorr Marcus , Nauck Matthias , Biffar Reiner , Volzke Henry , Baumeister Sebastian , Wallaschofski Henri

Background: Prospective studies showed that low serum testosterone concentrations are associated with various cardiometabolic risk factors and mortality. But the causal nature of these associations is controversial.Methods: We studied 1882 men aged 20–79 years with serum testosterone concentrations and genotyping data from the longitudinal population-based Study of Health in Pomerania.Testosterone concentrations were cross-sec...