Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep1062 | Thyroid | ECE2022

Breakfast with liquid levothyroxine (Levotirsol®): a single-center experience

D'Andrea Settimio , Berardicurti Antonella , Santarelli Livia , Vena Walter

Introduction: Levothyroxine (LT4) tablets are the most used treatment for hypothyroidism worldwide. LT4 tablets should be taken in the morning and have a fasting state. Some patients could be unable to adhere to this recommendation resulting in poor therapy compliance and thyrotropin (TSH) concentration above the upper normal limits. A previous double-blind placebo-controlled trial showed that LT4 liquid could be ingested during breakfast without a significant difference in TS...

ea0081p709 | Reproductive and Developmental Endocrinology | ECE2022

Serum testosterone mirrors inflammation parameteres in females admitted with covid-19 disease

Francesca Birtolo Maria , Vena Walter , Pizzocaro Alessandro , Jaafar Simona , Ciafardini Antea , Brunetti Alessandro , Pigni Stella , Mazziotti Gherardo , Lania Andrea

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is showing a rapid and continuous evolution in terms of new waves, the spread of variants and the evidence of reinfections. The growing heterogeneity of clinical presentation requires the identification of underlying pathogenic mechanisms to allow a better risk stratification. Previous studies analysed the role of sex hormones in disease severity demonstrating in male patients the association of...

ea0081oc8.1 | Oral Communications 8: Calcium and Bone | ECE2022

Effectiveness of anti-resorptive drugs on risk of vertebral fractures in women receiving aromatase inhibitors: a prospective study in real-life clinical practice

Mazziotti Gherardo , Vena Walter , Pigni Stella , Carrone Flaminia , Pedersini Rebecca , Cosentini Deborah , Torrisi Rosalba , Birtolo Maria Francesca , Maida Giulia , Berruti Alfredo , Lania Andrea

Bone loss is a frequent complication of aromatase inhibitors (AIs) therapy in women with breast cancer. Bone-active drugs are effective in protecting the skeleton from detrimental actions of AIs. However, bone mineral density (BMD) was the primary end-point in most of published studies, whereas data on fractures were scant and mainly limited to denosumab. In this prospective study, we investigated the effects of denosumab, oral bisphosphonates and intravenous zoledronate on ri...

ea0081p16 | Adrenal and Cardiovascular Endocrinology | ECE2022

Prevalence and clinical features of ARMC5 mutations in a single centre cohort of patients with bilateral adrenal incidentalomas

Frigerio Sofia , Morelli Valentina , Marta Elli Francesca , Vena Walter , Maffini Maria Antonia , Lucca Camilla , Piu Matteo , Mora Nicola , Palmieri Serena , Mantovani Giovanna , Arosio Maura

Introduction: Primary bilateral macronodular adrenal hyperplasia (PBMAH) is a rare cause of CushingÂ’s syndrome (CS). Some familial forms have been associated to gene ARMC5 (Armadillo repeat-containing protein 5) inactivating mutations. This study aimed to evaluate the prevalence and the complications of ARMC5 mutations in our cohort of patients with bilateral adrenal incidentalomas (BAI).Methods: 72 patients, referred to our Center...

ea0081p299 | Calcium and Bone | ECE2022

Impact of body composition on skeletal health in subjects with Klinefelter’s syndrome: a cross sectional study

Carrone Flaminia , Vena Walter , Delbarba Andrea , Chiara Pezzaioli Letizia , Facondo Paolo , Cappelli Carlo , Pizzocaro Alessandro , Mazziotti Gherardo , Lania Andrea Gerardo , Ferlin Alberto

Background: There is growing awareness of skeletal impairment in individuals with Klinefelter syndrome (KS), involving both quantitative and qualitative alteration of the bone as well as an increased prevalence of vertebral fractures (VFs). Beyond hypogonadism, considerable evidence suggests that other factors may be responsible for the skeletal fragility observed in these patients. Abnormal body composition is a common finding in KS subjects, characterized by an unfavourable ...

ea0081p309 | Calcium and Bone | ECE2022

Testosterone supplementation and bone parameters, a systematic review and meta-analysis study

Vena Walter , Corona Giovanni , Pizzocaro Alessandro , Giagulli Vito , Francomano Davide , Rastrelli Giulia , Aversa Antonio , Marcello Isidori Andrea , Pivonello Rosario , Vignozzi Linda , Mannucci Edoardo , Maggi Mario , Ferlin Alberto

Background: Testosterone (T) is essential for bone health during all ages, helping to achieve a proper peak bone mass and, later, to maintain bone density and strength. Guidelines on management of male osteoporosis recommend testosterone replacement in young-adult hypogonadal to prevent bone loss and anti-resorbitive drugs in case of high fracture risk, but the role of T replacement therapy (TRT) alone in subjects with late onset hypogonadism is still the object of an intense ...

ea0081p549 | Calcium and Bone | ECE2022

Artificial intelligence based on radiomic analysis of lumbar spine computed tomography (ct) scan may improve accuracy in detecting osteoporosis

Biamonte Emilia , Garoli Federico , Levi Riccardo , Vena Walter , Carrone Flaminia , Jafaar Simona , Fornari Maurizio , Grimaldi Marco , Politi Letterio , Lania Andrea , Mazziotti Gherardo

Background: Osteoporosis is characterized by reduced bone mass and a compromised bone microstructure, leading to increased bone fragility and fracture risk. Currently, the gold standard for diagnosis is the bone mineral density (BMD) measurement by DXA. However, approximately half of fragility fractures occurs in the context of normal or slightly decreased BMD values.Protocol: In this cross-sectional study, we performed an artificial intelligence (AI)-ba...

ea0063gp65 | Reproductive Axis | ECE2019

Testosterone replacement therapy outcomes in subjects with Klinefelter syndrome: preliminary results from a meta-analysis study

Vena Walter , Pizzocaro Alessandro , Pelliccione Fiore , Pivonello Rosario , Radicioni Antonio , Selice Riccardo , Rastrelli Giulia , Pasquali Daniela , Calogero Aldo Eugenio , Ferlin Alberto , Francavilla Sandro , Garolla Andrea , Corona Giovanni

Background: In patients with Klinefelter syndrome (KS) morbidity and mortality seem to be higher than general population, this depending on a wide number of possible comorbidities. Impaired metabolic profile, increased risk of venous thrombosis and the consequent increase of cardiovascular diseases might play a key role in this condition as well as reduced bone mineral density and higher fracture risk. Nowadays testosterone replacement therapy (TRT) is the first-choice treatme...

ea0070aep133 | Bone and Calcium | ECE2020

Prevalence and determinants of radiological vertebral fractures in a cohort of patients with Klinefelter syndrome

Vena Walter , Pizzocaro Alessandro , Amer Myriam , Indirli Rita , Maffezzoni Filippo , Ferrante Emanuele , Delbarba Andrea , Balzarini Luca , Ferlin Alberto , Mantovani Giovanna , Lania Andrea , Mazziotti Gherardo

Klinefelter syndrome (KS) is a frequent form of male hypogonadism that may be associated with a series of comorbidities potentially affecting quality of life and survival. As a matter of fact, KS was shown to negatively impact skeletal health. However, the studies so far published on this topic were mainly focused on evaluation ofbone mineral density (BMD) and bone microstructure, whereas data on fracture risk are still lacking. In this cross-sectional study, we evaluated for ...

ea0070aep779 | Reproductive and Developmental Endocrinology | ECE2020

Coagulation abnormalities in patients with klinefelter syndrome compared to age-matched healthy controls: Cross-sectional assessment by thrombin generation test

Indirli Rita , Profka Eriselda , Vena Walter , Cangiano Biagio , Pizzocaro Alessandro , Bonomi Marco , Clerici Marigrazia , Scalambrino Erica , Mazziotti Gherardo , Lania Andrea , Arosio Maura , Mantovani Giovanna , Tripodi Armando , Ferrante Emanuele

Introduction: Klinefelter syndrome (KS) is known to be associated with an increased risk of venous thromboembolism and arterial thrombosis, but the aetiology behind this prothrombotic status has not been fully elucidated. The aim of this study was to cross-sectionally investigate the coagulative state in subjects with KS compared to age-matched healthy males.Methods: Coagulation factors assessment, clinical characteristics collection and thrombin generat...