Endocrine Abstracts

BackgroundPrimary hyperparathyroidism (PHPT) is a common endocrine disorder accompanied by low total 25-hydroxyvitamin D [25(OH)D] levels. The 25(OH)D is converted to its biologically active form, 1.25-dihydroxyvitamin D [1.25(OH)2D] that then circulates as bound or free forms. Free 1.25(OH)2D concentrations in patients with PHPT have not previously been examined and understanding this is important to better assess vitamin ...

Background: Primary hyperparathyroidism (PHPT) is a common endocrine disorder accompanied by high cytokines and low total 25-hydroxyvitamin D [25(OH)D]. An inflammatory cytokine, monocyte chemoattractant protein-1 (MCP-1), is found to be higher in people with elevated parathyroid hormone (PTH), unlike other cytokines (1). Also, a rise in MCP-1 in response to high PTH is associated with bone loss (2). Parathyroidectomy (PTX) is the only cure for patients with PHPT. Whether the ...