Searchable abstracts of presentations at key conferences in endocrinology

ea0014p21 | (1) | ECE2007

Improved glucose metabolism and altered pancreatic structure in transgenic mice overexpressing betacellulin

Dahlhoff Maik , Herbach Nadja , Wanke Rüdiger , Wolf Eckhard , Schneider Marlon R.

Betacellulin, one of several peptides activating the EGFR (ErbB1) and related receptors, is a multipotent growth factor known to posses the unique ability to promote growth and differentiation of pancreatic β-cells.We investigated the effects of betacellulin overexpression in a recently established transgenic mouse model (Schneider et al., Endocrinology 146, 5237–5246, 2005). In transgenic animals, overall glucose metabolism was improved...