Searchable abstracts of presentations at key conferences in endocrinology

ea0099p415 | Adrenal and Cardiovascular Endocrinology | ECE2024

Bilateral adrenal haemorrhage secondary to heparin induced thrombocytopenia- a rare cause and presentation of adrenal crisis

Chirila Veronica , Bhattacharya Beas , Ward Alexandra

Case history: We present the case of a 73 year old lady who was admitted following a neck of femur fracture after a fall. She had surgery performed with no major complications. During her inpatient stay, she unexpectedly became very unwell, complaining of abdominal pain, low grade pyrexia, tachycardia, tachypnoea, hypotension, nausea and vomiting (1). Initial management was as sepsis of unknown source.Investigations: Bloods on admission (23/08/23): Hb 13...

ea0048wf7 | Workshop F: Disorders of the parathyroid glands, calcium metabolism and bone | SFEEU2017

Familial Hypocalciuric Hypercalacaemia

Jagannatha Hema , Allen Kate , Ward Alexandra , Chen Mimi

Sixty six year old gentleman was referred to clinic with hypercalcaemia. He suffered with low mood, “funny turns”, nocturia and loose stools with urgency to open bowels. He appeared tanned but no increase pigmentation in skin folds. There was no palpable lymphadenopathy or neck lump. The calcium levels were around three with low normal PTH of 3.7 (2.8 on repeat). He had not developed any complications like osteoporosis, fracture or renal stones secondary to hypercalc...

ea0025p330 | Thyroid | SFEBES2011

Should individuals with a Thy 3 result always undergo surgery?

Green Jessica , Hunt Toby , Mukhtar Rasha , Ward Alexandra , Allen Kate , Robinson Anthony , Maddox Paul

Introduction: British Thyroid Association Guidelines state that the diagnosis of thyroid malignancy cannot be based on the results of an aspiration’s cytology alone and will usually require surgical removal for confirmation. There has been much debate about the management of indeterminate fine needle aspirations (Thy 3). Recent publications have reported that the prevalence of thyroid carcinoma following a Thy 3 result to be as high has 28%, emphasising the importance of ...

ea0021oc5.3 | Steroids and thyroid | SFEBES2009

Differential roles of PAPSS1 and PAPSS2 in the control of androgen synthesis

McNelis Joanne , Idkowiak Jan , Nogueira Edson , Ward Alexandra , Dhir Vivek , Arlt Wiebke

A key component of androgen synthesis is the availability of the pro-hormone DHEA, which is either converted to active androgens or inactivated to its sulfate ester DHEAS by DHEA sulfotransferase (SULT2A1). The latter reaction requires provision of the universal sulfate donor 3′-phosphoadenosine-5′-phosphosulfate, PAPS. In humans, PAPS is generated by the PAPS synthase isoforms PAPSS1 and PAPSS2. Recently, inactivating PAPSS2 mutations have been identified i...