ea0005p180 | Neuroendocrinology and Behaviour | BES2003
Ward H
, Gardiner J
, Smith K
, Kong W
, Martin N
, Small C
, Ghatei M
, Bloom S
Cocaine and amphetamine regulated-transcript (CART) is highly expressed in the hypothalamus and was originally reported to be an endogenous satiety peptide. Intracerebroventricular injection of CART can result in motor abnormalities and recent studies have demonstrated increased food intake after intra-nuclear CART administration. To help clarify the situation CART was over-expressed in the hypothalamus using recombinant adeno-associated virus (rAAV-CART). Recombinant adeno-as...