Searchable abstracts of presentations at key conferences in endocrinology

ea0077p138 | Adrenal and Cardiovascular | SFEBES2021

Impact of COVID-19 on patients with primary adrenal insufficiency: a cross-sectional study

Knowles Gregory , Warmington Emily , Shepherd Lisa , Hazlehurst Jonathan , Bray Anne De , Gleeson Helena , Arlt Wiebke , Prete Alessandro

Background: Primary adrenal insufficiency (PAI) predisposes patients to infections, which can precipitate life-threatening adrenal crises. PAI patients are thought to be particularly vulnerable to COVID-19; however, little is known about its true impact on this group.Aim: To assess morbidity and health promotion attitudes during the COVID-19 pandemic amongst a large cohort of PAI patients.Methods: In May 2020 COVID-19 information, ...

ea0075a21 | Adrenal gland | EYES2021

Impact of COVID-19 on patients with primary adrenal insufficiency: A cross-sectional study

Knowles Gregory , Warmington Emily , Shepherd Lisa , Hazlehurst Jonathan , De Bray Anne , Gleeson Helena , Arlt Wiebke , Prete Alessandro

Background: Patients with primary adrenal insufficiency (PAI) carry an increased risk of infections which can precipitate adrenal crises. They are thought to be more likely to contract COVID-19 and develop severe disease; however, little is known about the true impact of COVID-19 on these patients.Objectives: To assess the response of a large single-centre cohort of PAI patients to COVID-19, focusing on morbidity and health promotion attitudes.<p cla...

ea0077op2.3 | Adrenal and Cardiovascular | SFEBES2021

PLK1 inhibitors as a new targeted treatment for adrenocortical carcinoma

Warmington Emily , Smith Gabrielle , Chortis Vasileios , Khan Sana , Lippert Juliane , Hantel Constanze , Liang Raimunde , Kiseljak-Vassiliades Katja , Wierman Margaret , Altieri Barbara , Fassnacht Martin , Foster Paul , Ronchi Cristina

Adrenocortical carcinoma (ACC) is an aggressive malignancy with limited treatment options. We identified polo-like kinase 1 (PLK1) as one of the most overexpressed genes and potential drug target in ACC. PLK1 inhibitors (PLK1i) are under evaluation in clinical trials for other malignancies, being more effective in TP53-mutated tumours. Here we test PLK1i efficacy in four ACC cell lines with different genetic background. Efficacy of three PLK1i (i.e. Volaserti...

ea0081rc5.7 | Rapid Communications 5: Diabetes, Obesity, Metabolism and Nutrition 2 | ECE2022

How do people with type 2 diabetes compare with type 1 diabetes in their outcomes of diabetes-related ketoacidosis?

Birchenough Amy , Krishnasamy Senthil , Saraf Sanjay , Owen Megan , Rajendran Dineshwaran , Ponniah Gobeka , Yip Wai Nga Alice , Warmington Emily , Hebbar Meghnaa , Sheikh Haaziq

Introduction: Diabetes-related ketoacidosis (DKA) is an acute endocrine emergency requiring immediate diagnosis and management. Common misconception is that DKA is associated with type 1 diabetes only. We explored the proportion of people with type 2 diabetes, and compared the management, complications and outcome of DKA between people with type 1 and type 2 diabetes.Methods: We conducted a retrospective study on people admitted with DKA across six hospi...

ea0081p345 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Understanding and improving the management of hyperosmolar hyperglycaemic state

Cuen Pan Carina Synn , Warmington Emily , Rengarajan Lakshmi , Cooper Catherine , Owen Megan , Sheikh Haaziq , Anilkumar Anjitha , Dhatariya Ketan , Webber Jonathan , Kempegowda Punith

Background: Hyperosmolar hyperglycaemic state (HHS) is an acute metabolic complication of diabetes that can lead to significant morbidity and mortality if managed incorrectly. With <1% prevalence, there is limited published literature available on HHS and most management guidelines worldwide are based solely on expert advice and opinions.Aims: To study the precipitating causes and identify baseline practises of HHS management, to highlight areas for ...

ea0081p597 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The impact of changes to Joint British Diabetes Societies’ diabetes-related ketoacidosis management guidelines on trends of complications and outcome

Ponniah Gobeka , Birchenough Amy , Owen Megan , Cuen Pan Carina Synn , Soghal Shamanth , Warmington Emily , Sheikh Haaziq , Ali Karamat Muhammad , Saraf Sanjay , Kempegowda Punith

Background: Serious complications of diabetes-related ketoacidosis (DKA) and its management with fixed rate insulin infusion (FRIII) include hypoglycaemia, hyperkalaemia and hypokalaemia. Revised Joint British Diabetes Societies for Inpatient Care (JBDS) guidelines in July 2021 recommended a reduced rate FRIII of 0.05 units/kg/hour from 0.1 units/kg/hour once blood glucose levels fall to ≤14.0 mmol/l to alleviate the risk of these complications.Aim...

ea0075o10 | Obesity, metabolism &amp; miscellaneous endocrinology | EYES2021

Use of pre-lecture Concise Medical Information Cines (CoMICs) to enhance learning in medical school

Evans Nia , Delson Dwi , Ooi Emma , Warmington Emily , Shabbir Dania , Ng Cai Ying , Piya Simran , Han Seunghee , Chee Yap Soon , Melson Eka , Davitadze Meri , Kempegowda Punith

Objectives: Pre-clinical medical education is mainly delivered in didactic large-group lectures, where complex new terminology and concepts are introduced. Mounting evidence suggests that pre-class activities introducing new material can increase student performance. Concise Medical Information Cines (CoMICs) compresses information on various diseases into 5-minute videos. This study assessed the effectiveness of CoMICs as a pre-lecture resource to enhance learning and motivat...

ea0081p581 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Comparing global rating scores from simulation-based diabetes and endocrine scenarios between healthcare professionals of high- and low- and middle-income countries

Abdi Zakee , Zhou Dengyi , Malhotra Kashish , Ali Anisah , Sheikh Jameela , Sakthivel Pavithra , Warmington Emily , Cuen Pan Carina Synn , Chen Wentin , Kaur Harjeet , Nirmal Rachel , Soran Vina , Allison Isabel , Evans Nia , Delson Dwi , Davitadze Meri , Kempegowda Punith , Simulation Simba

Background: Simulation via Instant Messaging - Birmingham Advance (SIMBA) is an online simulation learning modality designed to recreate clinical scenarios, allowing participants to increase their confidence in a safe environment without compromising patient safety. The global rating scale (GRS) is a commonly used assessment tool in medical schools to assess participant competence and skills. Following SIMBA sessions, an independent assessor anonymously scores participants&#14...

ea0086p63 | Metabolism, Obesity and Diabetes | SFEBES2022

Is SIMBA impactful in improving participants’ confidence in managing cases of obesity via simulation-based learning, irrespective of the mode of attendance or country of residence?

Abdi Zakee , Sakthivel Pavithra , Warmington Emily , Ali Anisah , Elhairy Maiar , Devi Bucktowar Anoushka , Elghobashy Mirna , Ravi Sangamithra , Zhou Dengyi , Synn Cuen Pan Carina , Hazlehurst Jonathan , Kempegowda Punith , behalf of SIMBA and CoMICs team On

Introduction: Simulation via Instant Messaging - Birmingham Advance (SIMBA) is a simulation learning modality designed to recreate real-life clinical scenarios, in a safe environment to help improve participants’ confidence in solving such cases.Objective: To study SIMBA’s effectiveness in improving confidence in managing obesity-related cases and whether the country of residence and modality of attendance influence change in confidence.<p ...

ea0086p336 | Metabolism, Obesity and Diabetes | SFEBES2022

Comparison of global rating scale scores of Simulation via Instant Messaging -Birmingham Advance (SIMBA) participants from high- and low- and middle-income countries of residence

Sakthivel Pavithra , Abdi Zakee , Zhou Dengyi , Malhotra Kashish , Ali Anisah , Sheikh Jameela , Warmington Emily , Synn Cuen Pan Carina , Chen Wentin , Kaur Harjeet , Nirmal Rachel , Soran Vina , Allison Isabel , Evans Nia , Delson Dwi , Davitadze Meri , Kempegowda Punith , team SIMBA

Introduction: Simulation via Instant Messaging -Birmingham Advance (SIMBA) is a virtual platform which simulates anonymised, real-life clinical cases to train healthcare professionals. Participants’ competence is assessed using an adapted version of the global rating scale (GRS) commonly used in medical schools.Aims: To compare GRS scores of participants according to country of residence and domains assessed as part of simulation.<p class="abste...