Endocrine Abstracts

Case: Acromegaly is associated with osteoarthritis due to soft tissue swelling. Our patient was first diagnosed with acromegaly in 2001 at the age of 51, subsequently undergoing a transsphenoidal pituitary adenoma resection in 2002, followed by postoperative radiotherapy in 2003, with subsequent development of anterior hypopituitarism. He has comorbidities of osteoarthritis, (having previously undergone bilateral total hip replacements and a left total knee replacement), bunio...

Acromegaly is associated with osteoarthritis due to soft tissue swelling. Our patient was first diagnosed with acromegaly in 2001 at the age of 51, subsequently undergoing a transsphenoidal pituitary adenoma resection in 2002, followed by postoperative radiotherapy in 2003, with subsequent development of anterior hypopituitarism. He has comorbidities of osteoarthritis, (having previously undergone bilateral total hip replacements and a left total knee replacement), bunionectom...

Introduction: Weight gain and its associated adverse health consequences have become a significant aspect of the life experience of many people with schizophrenia and other severe enduring mental illnesses (SMIs). Glucagon-like peptide -1(GLP-1) receptor agonists could be of substantial value in addressing this unmet need. We aimed to determine whether semaglutide treatment is feasible and acceptable to individuals in an inpatient setting and successful in facilitating weight ...

Introduction: Glucagon-like peptide-1(GLP-1) agonists are widely used for treatment of type 2 diabetes(T2D). To date a number of reports have described improvements in glucose control with the addition of a GLP-1 agonist to the insulin regime in treatment of type 1 diabetes(T1D). From a physiological perspective there is credence to the notion that a GLP-1 agonist will lower glucose levels in people with T1D as they do in T2D. GLP-1 is an endogenous hormone th...

Design: Macroprolactinemia may influence the interpretation of serum prolactin levels – a recognised phenomenon since 19781. The degree of macroprolactinaemia over time is less well described. We determined how macroprolactin status (based on polyethylene glycol (PEG) precipitation varied by analysing serial measurements in hyperprolactinaemic individuals over nine years.Patients and Measurements: Results from 1810 individuals were includ...

Background: Inherited metabolic disorders (IMDs) are a group of heterogenous genetic disorders resulting in substrate accumulation, energy deficiency or complex molecular defects due to the failure of specific molecules to act as enzymes, cofactors, transporters, or receptors in specific metabolic pathways. The pathophysiological changes seen in IMDs sometimes impact on the endocrine system. We here describe our experience at one UK centre where patients are seen jointly by an...

Introduction: Primary hypothyroidism affects about 3% of the general population in Europe. In most cases, people are treated with Levothyroxine. In relation to the recent British Thyroid Association guidance and the 2020 Competitions and Marketing Authority (CMA) ruling, we examined prescribing data for levothyroxine, NDT and liothyronine by dose, regarding changes from 2016 to 2022.Design: Monthly primary care prescribing data for each British National ...

Introduction: Microvascular and macrovascular complications in type 1 diabetes T1D) may be linked to endothelial stress due to glycaemic variability. This work aimed to examine whether determination of glycaemic parameters including glucose variability (GV) over an 18month period is associated with microvascular clinical sequelae. Methods: Freestyle Libre 15-minute glucose values were downloaded for 89 T1DM individuals for up to 18 months from 2021 to 20...