Searchable abstracts of presentations at key conferences in endocrinology

ea0086p28 | Bone and Calcium | SFEBES2022

Is finger prick blood collection using Mitra® volumetric absorptive microsampling (VAMS) device a viable alternative to venous for testosterone, cortisol, 25 hydroxyvitamin D and bone resorption marker β-CTX measurements?

Dunn Rachel F , Washbourne Christopher J , Greeves Julie , Fraser William D , Tang Jonathan C Y

Background: Volumetric absorbent microsampling (VAMS) provides a less intrusive alternative to venepuncture when collecting blood samples for diagnostic testing. A small, precisely determined amount of capillary blood from a single finger-prick is absorbed into a medium for storage, from which it can later be extracted and analysed. In this study, we developed methods to measure four commonly requested endocrine/bone biomarkers for finger-prick blood samples analysis, and inve...

ea0044p61 | Bone and Calcium | SFEBES2016

FGF23, iron and vitamin D metabolism in chronic kidney disease

Piec Isabelle , Chipchase Allison , Nicholls Holly , Tang Jonathan , Washbourne Christopher , Fraser William D

Introduction: In CKD, net effects of declining kidney function and increasing FGF23 (and PTH) concentrations on vitamin D catabolism and iron metabolism are not clear.Objectives: Compare the Biomedica to the ImmutopicsÂ’ immunoassay for measurement of cFGF23. Determine the relationship between iron status; vitamin D and intact FGF23 (iFGF23) and c-terminal (cFGF23) concentrations in blood.Method: Samples from routine care and a...

ea0044p72 | Clinical biochemistry | SFEBES2016

Changes in serum 25-hydroxyvitamin D, 24,25-dihydroxyvitamin D and 1,25-dihydroxyvitamin D in response to three vitamin D3 supplementation regimens

Tang Jonathan , Nicholls Holly , Dutton John , Piec Isabelle , Washbourne Christopher , Saleh Lanja , Novak A , Close Graeme , Macdonald Helen , Fraser William

Background: 25-hydroxyvitamin D (25(OH)D) is metabolised into two forms of metabolites: 1,25-dihydroxyvitamin D (1,25(OH)2D) by the actions of 1α hydroxylase, and 24,25-dihydroxyvitamin D (24,25(OH)2D) by 24-hydroxylase. Studies suggest the production of 1,25(OH)2D is 24,25(OH)2D dependent. Genetic mutations of CYP24A1 gene resulting in reduced or total loss of 24-hydroxylase function are associated with hypercalcaemic condition...

ea0059oc1.2 | Translational highlights | SFEBES2018

Vitamin D insufficiency and elevated vitamin D metabolite ratios (VMR) are associated with increased risk of injuries: Results from the british army lower limb injury prevention (ALLIP) study

Tang Jonathan , Jackson Sarah , Izard Rachel , Oliver Samuel , Piec Isabelle , Washbourne Christopher , Walsh Neil , Greeves Julie , Fraser William

Introduction: British Army recruits suffer from musculoskeletal injuries (MSI) during initial training. Up to 10% suffer skeletal stress fracture (SFx) resulting in lost training days and medical attrition. There is evidence to suggest that vitamin D deficiency is prevalent in the army. Our aim was to determine vitamin D metabolites (VDM) in recruits upon starting training, and health outcomes after a 14-week training programme.Methods: ...