Searchable abstracts of presentations at key conferences in endocrinology

ea0013p330 | Thyroid | SFEBES2007

Plasminogen activators in human thyroid follicular cells

Susarla Radhika , Watkinson John C , Eggo Margaret C

Human thyroid follicular cells in culture synthesise plasminogen activators, both urokinase (uPA) and tissue-type (tPA). The PAs secreted into the culture medium were active (2.5–50 U/ml) and able to mediate the conversion of plasminogen to plasmin. Secreted PA activity (PAA) was markedly increased by epidermal growth factor (EGF) and protein kinase C (PKC) activation with TPA. There was a corresponding increase in uPA and tPA mRNA levels and in uPA and tPA protein secret...