Searchable abstracts of presentations at key conferences in endocrinology

ea0013p292 | Thyroid | SFEBES2007

The calcium-sensing receptor is a target of autoantibodies in patients with autoimmune polyendocrine syndrome type 1

Gavalas Nikos , Kemp Elizabeth , Krohn Kai , Brown Edward , Watson Philip , Weetman Anthony

Autoimmune polyendocrine syndrome type 1 (APS1) is a rare autosomal recessive disorder caused by mutations in the autoimmune regulator gene. Major disease components include mucocutaneous candidiasis, hypoparathyroidism and AddisonÂ’s disease. Acquired hypoparathyroidism (AH) occurs in 80% of APS1 patients and is associated with hypocalcaemia, hyperphosphataemia and low serum levels of parathyroid hormone (PTH). Reports suggest that these clinical symptoms are initiated by...