Searchable abstracts of presentations at key conferences in endocrinology

ea0081p524 | Adrenal and Cardiovascular Endocrinology | ECE2022

HIF-2α is detrimental for the functioning of the adrenal medulla

Watts Deepika , Bechmann Nicole , Mohr Hermine , Kruger Anja , Pellegata Natalia S. , Eisenhofer Graeme , Peitzsch Mirko , Wielockx Ben

The adrenal gland is a crucial regulator of numerous fundamental biological processes and its hormones are essential for maintaining homeostasis in normal and stressful situations. However, the impact of hypoxia signalling on the function of the adrenal remains poorly understood. During the past years, our research group has focused on enhancing our understanding of hypoxia pathway proteins (HPPs) in the different areas of the adrenal gland. Firstly, we described a crucial rol...

ea0081ep55 | Adrenal and Cardiovascular Endocrinology | ECE2022

The asymmetric adrenal in mice and men: Sexual dimorphism and potential hormonal consequences

Bechmann Nicole , Moskopp Mats Leif , Watts Deepika , Steenblock Charlotte , Kanczkowski Waldemar , Wielockx Ben , Bornstein Stefan R , Peitzsch Mirko , Eisenhofer Graeme

Evidence indicates that the adrenals are sexually dimorphic and asymmetric. These differences may have implications for the prevalence and progression of adrenal diseases, which also show asymmetry and sexual dimorphism. The present study aims to characterize the morphological and metabolic differences associated with adrenal sex and asymmetry in mice and humans. Adrenals were compared bilaterally in male and female C57B/6NRj mice with regard to morphological and hormonal char...

ea0081p20 | Adrenal and Cardiovascular Endocrinology | ECE2022

Characterization of adrenal miRNA-based dysregulations in Cushing’s Syndrome

Zhang Ru , Vetrivel Sharmilee , Watts Deepika , Osswald Andrea , Engel Mareen , Beuschlein Felix , Chen Alon , Sbiera Silviu , Wielockx Ben , Reincke Martin , Riester Anna

Introduction: Transcriptional regulation of gene expression by miRNAs is critical for the fine-tuning of stress response. However, its role in hypercortisolism has not been explored well. After exploring circulating miRNAs in CushingÂ’ Syndrome (CS) as biomarkers our aim was to investigate their origin and their role in adrenal tissue.Methods: Next generation sequencing (NGS) based miRNA profiling was performed in adrenal samples from patients of Ger...