Searchable abstracts of presentations at key conferences in endocrinology

ea0034p421 | Thyroid | SFEBES2014

Treatment with a TRα1 antagonist increases bone mineral content

Waung Julian A , Bassett J H Duncan , Williams Graham R

Thyroid hormones regulate adult bone turnover. Thyrotoxicosis results in high turnover osteoporosis whilst hypothyroidism leads to low bone turnover with increased bone mass and mineralisation. T3-target tissues express thyroid hormone receptor alpha (TRα), thyroid hormone receptor beta (TRβ)or both receptors. TRα1 mediates the actions of T3 in bone and in skeletal cells TRα1 mRNA expression is 12-fold higher than TRβ1. Accordingl...

ea0037ep732 | Pituitary: clinical | ECE2015

Efficacy and safety of tolvaptan in treatment of SIADH; case-series from 2 UK hospitals

Tzoulis Ploutarchos , Waung Julian , Khoo Bernard , Cohen Mark , Bouloux Pierre-Marc

Introduction: Contrary to US guidelines, recent European guidelines do not recommend tolvaptan for the treatment of SIADH.Methods: Retrospective data collection of all inpatients treated with tolvaptan for SIADH in two UK hospitals between November 2010 and February 2014. All values were calculated as mean±S.D.Results: This case series included 61 patients (33 females, 28 males) aged 74.4±15.3 years with se...