Searchable abstracts of presentations at key conferences in endocrinology

ea0012p133 | Thyroid | SFE2006

Does L-thyroxine reduce weight in people with subclinical hypothyroidism?

Razvi S , Pearce SH , Weaver JU

ObjectiveIt is controversial whether subclinical hypothyroidism (SCH) always reflects mild thyroid failure and if treatment is beneficial. The arguments in favour of treatment are prevention of progression, reducing cholesterol levels and improving symptoms. The consequence of SCH on body weight and its response to treatment has never been studied in a systematic manner.MethodsUnselected population-based stud...

ea0011p790 | Thyroid | ECE2006

Quality of life, health status, symptoms and treatment satisfaction in subclinical hypothyroidism: a double - blind 12-week cross - over study of L-thyroxine versus placebo

Razvi S , McMillan CV , Weaver JU

Background: It is controversial whether symptoms of hypothyroidism and quality of life (QoL) in people with subclinical hypothyroidism (SCH) are impaired and whether treatment with L-thyroxine alleviates these. Previous studies of L-Thyroxine therapy have shown conflicting results. No previous study has simultaneously 1investigated effects of treatment on quality of life (QoL), health status, symptoms and treatment satisfaction.Methods: One hundred patie...

ea0012p88 | Pituitary | SFE2006

Massively elevated serum prolactin without galactorrhoea in man with a giant prolactinoma

Ravikumar B , Newby M , Handley G , Weaver JU

A 55 year old gentleman, previously fit and well, presented with an insidious onset of visual disturbance, tiredness and frontal headaches over 2 years, which had been worsening during the previous 3 months. A routine optician review revealed bi-temporal hemianopia and prompted endocrine referral. Apart from superior bi-temporal hemianopia, clinical examination was otherwise normal. Serum prolactin levels were grossly elevated at 544,800 mU/l with no macroprolactin. Despite th...

ea0012p107 | Reproduction | SFE2006

Prevalence of assay interference in women with high serum testosterone levels

Ravikumar B , Handley G , Weaver JU , Oxynos C , Narayanan KR

Index case and aimsA 26 year old woman was referred to our endocrine clinic with infertility and raised testosterone levels. Clinical examination was completely normal, with no hirsuitism or virilizing features. She had normal gonadotropin and SHBG levels, but had elevated testosterone (6.6 nmol/l (0.5–2.8) and dehydroepiandrosterone sulphate (DHEA-S) levels (13.5 umol/l (1.4–11.1)). To exclude the possibility of interference in our direct assa...