Searchable abstracts of presentations at key conferences in endocrinology

ea0018p35 | (1) | MES2008

An unusual case of primary infertility

Amin Anjali , Robinson Stephen , Webber Lisa

We present a case of a 29-year-old lady who presented with subfertility. She had had a 2 years history of oligomenorrhoea with highly irregular menses. She had symptoms of depression and described tunnel vision. Clinically, she was euendocrine with no features of hormonal excess or deficiency. She was not hirsute. Visual field testing demonstrated a severe left superior temporal quadrantopia.Laboratory investigations demonstrated an oestriadol level rang...

ea0025p158 | Diabetes, metabolism and cardiovascular | SFEBES2011

Effect of diet/lifestyle advice on weight change in an unselected polycystic ovary syndrome (PCOS) population

Sinha Khushboo , Albeyatti Abdullah , White Davinia , Franks Stephen , Webber Lisa

Objectives: To examine the effect on weight change of diet/lifestyle advice to maintain/achieve a healthy weight in an unselected PCOS population.Methods: All overweight patients attending the Reproductive Endocrine clinic with PCOS are routinely given lifestyle advice for weight loss by their consultant, offered referral to see a dietician and, when clinically appropriate, prescribed orlistat. Clinical notes were reviewed for 50 consecutive patients wit...

ea0065p350 | Reproductive Endocrinology and Biology | SFEBES2019

Gonadotrophin rise following the kisspeptin analogue (MVT-602) is increased in women with hypothalamic amenorrhoea compared to healthy women

Eng Pei Chia , Abbara Ali , Phylactou Maria , Clarke Sophie A , Yang Lisa , Mills Edouard , Modi Manish , Papadopoulou Deborah , Plumptre Isabella , Hunjan Tia , Purugganan Kate , Webber Lisa , Salim Rehan , Comninos Alexander N , Dhillo Waljit S

Introduction: Hypothalamic amenorrhoea (HA) is a condition characterised by reduced GnRH pulsatility and is a common cause of anovulatory subfertility. Kisspeptin is an endogenous neuropeptide that regulates hypothalamic GnRH function. Hypothalamic kisspeptin expression is reduced, and kisspeptin receptor expression is increased, in a rodent model of HA. The kisspeptin analogue MVT-602 has a 3-4-fold longer half-life than native kisspeptin-54 (t1/2 0.5 h). We invest...

ea0070aep799 | Reproductive and Developmental Endocrinology | ECE2020

Investigation of the mechanism of action of duodenal mucosal resurfacing in insulin resistant women with polycystic ovarian syndrome. the DOMINO multicentre randomised controlled trial

Dimitriadis Georgios K. , Kaur Vasha , Pérez-Pevida Belen , Bansi Davinder , Jayasena Channa , Bate Danielle , Fielding Barbara , Balfoussia Danai , Webber Lisa , Miao Yun , Mears Frederick , Jackson Nicola , Coppin Lucy , Johnson Brett , Umpleby Margot , Randeva Harpal S , Miras Alexander D

Introduction: Duodenal mucosal resurfacing (DMR) is a novel therapy for T2DM. It involves the hydrothermal ablation of up to 14 cm of the duodenal mucosa through a specially designed endoscopic catheter. The procedure is performed under general anaesthesia, patients are discharged the same day and it does not involve the implantation of a foreign body. Cohort studies have demonstrated that DMR induces meaningful hbA1c reductions of 0.9–1.4% by 3 months that are largely m...