Searchable abstracts of presentations at key conferences in endocrinology

ea0063p263 | Pituitary and Neuroendocrinology 1 | ECE2019

Baseline characteristics of adult patients with growth hormone deficiency (GHD) enrolled in NordiNet® International Outcome Study (IOS): are there variations between countries?

Weber Matthias M , Pietropoli Alberto , Hoybye Charlotte

Czech Republic background: NordiNet® IOS (NCT00960128), a non-interventional study (2006–2016), assessed the effectiveness and safety of real-life treatment with Norditropin. From 23 countries, 2,321 adults with GHD were included; 971, GH-naïve at baseline, were included in the effectiveness analysis set (EAS). Baseline characteristics in the six largest contributing countries were evaluated.Methods: Patient information was ente...

ea0014p463 | (1) | ECE2007

Genotype-phenotype correlation in Romanian patients with classical forms of 21-hydroxylase deficiency

Zimmermann Anca , Grigorescu Sido Paula , Al-Khzouz Camelia , Nistor Tiberiu , Weber Matthias M , Schulze Egbert

Congenital adrenal hyperplasia (CAH) comprises autosomal recessive disorders mainly due to defects in the 21-hydroxylase (CYP21) gene. We aimed to perform a genotype-phenotype analysis in Romanian patients with classical 21-hydroxylase deficiency.Patients and methods: We included 42 patients (13 males, 29 females, 19 with the salt wasting (SW) form, 29 with the simple virilizing (SV) form. Molecular analysis was performed by direct sequencing of PCR ampl...

ea0022p2 | Adrenal | ECE2010

Alterations in lipid and carbohydrate metabolism in patients with classic CAH due to 21-hydroxylase deficiency

Zimmermann Anca , Sido Paula Grigorescu , Khzouz Camelia Al , Patberg Karen , Bucerzan Simona , Schulze Egbert , Zimmermann Tim , Weber Matthias M

Background: Classic 21-hydroxylase deficiency (21HD) presents some traits of the metabolic syndrome. We aimed to characterize discrete alterations of lipid and carbohydrate metabolism in children and young adults with classic 21HD, which could predict early atherogenesis.Design: Cross-sectional comparative.Patients and methods: Of 27 Caucasian patients with classic 21HD (4–31 years); 27 sex-, age- and BMI-matched controls. Cli...

ea0022p229 | Clinical case reports and clinical practice | ECE2010

Dose of growth hormone (GH) and not IGFI level at treatment start influences treatment outcome in GH deficient adults (GHDA): Data from the NordiNet International Outcome Study (IOS)

Jorgensen Jens Otto L , Weber Matthias M , Hoybye Charlotte , Pedersen Birgitte T , Rakov Viatcheslav , Christiansen Jens Sandahl

Background: Serum IGFI measurements are used during GH replacement in GHDA for titration of the GH dose, to monitor compliance and to avoid overdosing, but it is uncertain if pretreatment IGFI is a determinant of the GH dose or the response to GH treatment.Methods: Data from the NordiNet IOS have been analyzed to determine pretreatment serum IGFI concentrations in GHDA and to analyze if they influence the GH starting dose and/or the therapeutic response ...

ea0022p264 | Developmental endocrinology | ECE2010

Baseline characteristics and serum IGF1 levels in GH deficient (GHD) patients treated in the transition phase from adolescence into adulthood: data from the NordiNet International Outcome Study (IOS)

Weber Matthias M , Blankenstein Oliver , Jorgensen Jens Otto L , Pedersen Birgitte T , Rakov Viatcheslav , Christiansen Jens Sandahl

Background: Data from several clinical studies have demonstrated the benefit of GH treatment in relation to bone mineral density and body composition in young adults who received GH treatment in childhood due to GHD1–3. There are recommendations to use a higher GH dose in the transition phase compared to the GH dose required during adulthood to mimic the endogenous GH secretion4,5.Methods: Data from NordiNet IOS have been analy...

ea0041ep920 | Pituitary - Clinical | ECE2016

Fatigue and subjective complaints in patients with active and controlled acromegaly: a cross sectional multi-center study

Zimmermann Anca , Zwerenz Rudiger , Droste Michael , Schofl Christof , Strasburger Christian J , Plockinger Ursula , Honegger Jurgen , Millaku Bledar , Beutel Manfred E , Weber Matthias M

Introduction: Acromegalic patients (AP) often report fatigue and chronic subjective complaints. We aimed to investigate in more detail these aspects in AP, dependent on disease activity, age, gender, medication and pituitary insufficiency (PI).Patients/methods: Cross sectional, 124 patients (M/W 51/73, age 58.3±14.7 years, 49/75–active/controlled disease). The patients completed the Multidimensional Fatigue Inventory (MFI-20) and the Giessen Su...