Searchable abstracts of presentations at key conferences in endocrinology

ea0066p79 | Pituitary | BSPED2019

A case of 17 years old beta thalassaemic boy with polyendocrinopathy secondary to hemosiderosis

Moshanova Tatyana , Bhake Ragini , Webster Amy , Greening James

The main-stay management of Beta thalassaemia major is blood transfusion but this carries a risk of endocrinopathy from hemosiderosis in endocrine organs. Iron chelation therapy aims to mitigate this risk. Access to this therapy isn’t available in some healthcare systems. Known Syrian refugee diagnosed with Beta thalassaemia major in infancy referred via the refugee medical services for thalassaemia management. There was previous history of intermittent transfusion suppor...

ea0060oc3 | (1) | UKINETS2018

PUnNETS (Prediction of Unknown Neuroendocrine Tumour Site) – a DNA methylation-based classifier

Berner Alison M , Pipinikas Christodoulos , Karpathakis Anna , Dibra Harpreet K , Moghul Ismail , Webster Amy , Luong Tu Vinh , Thirlwell Christina

Neuroendocrine tumours (NETs) of unknown primary (UP-NETs) represent up to 22% of NETs. Primary site identification enables patients to access appropriate treatment but is not always possible by immunohistochemistry or imaging. Given the epigenetic dysregulation of NETs, we aimed to use methylation array data to determine UP-NET tissue-of-origin. DNA from formalin-fixed paraffin embedded tissue from 76 pancreatic NET (PanNETs) (54 training and 22 validation samples) and 53 sma...