Searchable abstracts of presentations at key conferences in endocrinology

ea0065p2 | Adrenal and Cardiovascular | SFEBES2019

11β-HSD1 mediates muscle atrophy induced by glucocorticoid therapy in chronic inflammatory disease

Webster Justine Michelle , Fenton Chloe , Lavery Gareth , Langen Ramon , Hardy Rowan

Objective: Therapeutic glucocorticoids (GCs) are used to treat chronic inflammatory disease, due to their anti-inflammatory effects. Despite their efficacy, chronic exposure to GCs elicits undesirable side effects, including muscle atrophy. 11 beta-hydroxysteroid dehydrogenase 1 (11β-HSD1) activates GCs within muscle, is induced by inflammation, and has previously shown to drive GC-induced muscle wasting. We examined the role of 11β-HSD1 in mediating muscle wasting i...