Searchable abstracts of presentations at key conferences in endocrinology

ea0011s7 | Clinical Endocrinology Trust Lecture | ECE2006

Thyroid disease paradigms and problems

Weetman AP

It is the 50th anniversary of the discovery of thyroid autoimmunity by Rose and Witebsky in suitably immunised rabbits and then by Doniach and Roitt who identified thyroglobulin antibodies in the serum of patients with Hashimoto’s thyroiditis. This is really the exemplar or paradigm of an autoimmune disease and subsequent discoveries have provided new paradigms. Graves’ disease is a prime example of disease apparently caused exclusively by an autoantibody while unrav...

ea0019p369 | Thyroid | SFEBES2009

Epitopes for calcium-sensing receptor antibodies in patients with autoimmune polyendocrine syndrome type 1 are located in the N-terminal of the extracellular domain

Kemp EH , Gavalas NG , Akhtar S , Krohn KJE , Brown EM , Watson P , Weetman AP

Context: Autoimmune polyendocrine syndrome type 1 (APS1) is an autosomal recessive disorder caused by mutations in the autoimmune regulator gene. Hypoparathyroidism occurs in 80% of patients with APS1 and has been suggested to result from an autoimmune reaction against the calcium-sensing receptor (CaSR) on parathyroid cells. Previously, we have detected CaSR-binding antibodies in patients with APS1 using immunoprecipitation and flow cytometry assays.Obj...