Searchable abstracts of presentations at key conferences in endocrinology

ea0090p478 | Thyroid | ECE2023

Mouse model of Graves’ ophthalmopathy induced by the immunization with TSHR A and IGF-1Rα subunit gene

Zheng Wei , Wu Ruixin , Li Ning , Wang Xuan , Wang Shen , Tan Jian

Background: The study aimed to establish a mouse model of Graves’ disease (GD) with Graves’ ophthalmopathy (GO; GD+GO) that can represent the clinical disease characteristics.Methods: A eukaryotic expression plasmid of insulin-like growth factor 1 receptor (IGF-1R) α subunit (pcDNA3.1/IGF-1Rα) and a thyrotropin receptor (TSHR) A subunit plasmid (pcDNA3.1/TSHR-289) were injected in female BALB/c mice to induce a GD+GO model. Grouping w...

ea0070aep733 | Pituitary and Neuroendocrinology | ECE2020

Tobacco smoke induces aberrant pulmonary neuroendocrine differentiation via different MAPK pathways

Liang Zhaofeng , Xie Wei , Wu Rui , Xie Chunfeng , Li Xiaoting , Zhong Caiyun

Tobacco smoke (TS) is the major cause of lung cancer, including pulmonary neuroendocrine tumors such as small cell lung cancer and large cell neuroendocrine carcinoma. Unlike squamous cell carcinomas and adenocarcinomas, the precursor lesions for subtypes of pulmonary neuroendocrine tumors have not been historically defined, and theexpression of neuroendocrine markers has been served as critical indices for the identification of these tumors. Mitogen-activated protein kinases ...

ea0097002 | Section | BES2023

Protein tyrosine phosphatase receptor kappa regulates glycolysis, lipid metabolism and promotes hepatocyte reprogramming in obesity

Eduardo H Gilglioni , Li Ao , Wadsen St-Pierre-Wijckmans , Tzu-Keng Shen , Israel Perez-Chavez , Garnik Hovhannisyan , Daria Ezerina , Michela Lisjak , Andre Dias , Javier Negueruela , Mamnez Julia Bauza- , Jose Maria Herranz , Stephane Demine , Zheng Feng , Thibaut Vignane , Lukas Otero , Flavia Lambertucci , Alena Prasnicka , Jacques Deviere , Jose Antonio Encinas , Sumeet Pal Singh , Joris Messens , Milos Filipovic , Eric Trepo , Hayley Sharpe , Wei Wu , Esteban N Gurzov

Fat accumulation, lipogenesis and glycolysis are key contributors to hepatocyte metabolic reprogramming and the pathogenesis of non-alcoholic liver fatty liver disease (NAFLD). The molecular mechanisms affected by steatosis and inflammation in the obese state remain unknown. Here we report that obesity leads to dysregulated expression of protein-tyrosine phosphatases in human livers. Protein Tyrosine Phosphatase Receptor Kappa (PTPRK) levels were increased in hepatocytes by st...