Searchable abstracts of presentations at key conferences in endocrinology

ea0073ep128 | Endocrine-Related Cancer | ECE2021

A neuroendocrine tumour presenting with double vision

Boharoon Hessa , Wernig Florian

Carcinoid tumours are low grade neoplasms usually arising from neuroendocrine cells of the bronchial and gastrointestinal tracts. Carcinoid tumours metastasise in 50–75% of patients, most commonly to lymph nodes, liver, and bones, but intra-orbital metastases have only rarely been reported. Here, we describe a patient who presented with an intra-orbital neuroendocrine tumour which was successfully treated with surgery and radiotherapy. A 70-year-old female patient present...

ea0077lb3 | Late Breaking | SFEBES2021

The importance of high-volume specialist centres. An audit of bilateral adrenal vein catheterization success rates

Alsafi Zaid , Wernig Florian , Alsafi Ali

Background: Adrenal vein sampling (AVS) is the gold-standard for localizing the site of autonomous aldosterone production in patients with primary aldosteronism (PA). The procedure is technically challenging with a reported success rate of 50-95%.Aim: To audit the success rate of AVS at a regional referral unit.Standards: No set standard exists. 80% success rate was taken as the minimum acceptable standard for a tertiary referral c...

ea0077lb53 | Late Breaking | SFEBES2021

Central diabetes insipidus as initial presentation of Acute myeloid Leukaemia monosomy 7

Qayum Ambreen , Palanicawandar Renuka , Wernig Florian

Introduction: The association of central diabetes insipidus (CDI) and acute myeloid leukaemia is rare. The onset of CDI is variable during the disease course and can be a presenting feature of AMLCase: : A 75 years old Caucasian male patient presented with acute right sided abdominal pain. His initial CT abdomen was normal. He had normocytic anaemia, thrombocytosis and monocytosis. A repeat CT scan 3 days later showed bilateral swollen adrenal glands and...

ea0050p262 | Neuroendocrinology and Pituitary | SFEBES2017

Establishing the prevalence of pituitary involvement in patients with IgG4-related disease.

Smith Christopher , Pusey Charles , Wernig Florian

Background: IgG4-related disease is a rare immune-mediated inflammatory condition associated with extensive multi-organ involvement. Little is known about the epidemiology of pituitary involvement as a part the IgG4-related disease spectrum.Objectives: We aimed to identify patients with pituitary involvement amongst those with systemic IgG4-related disease, and to compare these individuals to patients with isolated ...

ea0050p262 | Neuroendocrinology and Pituitary | SFEBES2017

Establishing the prevalence of pituitary involvement in patients with IgG4-related disease.

Smith Christopher , Pusey Charles , Wernig Florian

Background: IgG4-related disease is a rare immune-mediated inflammatory condition associated with extensive multi-organ involvement. Little is known about the epidemiology of pituitary involvement as a part the IgG4-related disease spectrum.Objectives: We aimed to identify patients with pituitary involvement amongst those with systemic IgG4-related disease, and to compare these individuals to patients with isolated ...

ea0062p63 | Poster Presentations | EU2019

Prednisolone replacement makes steroid optimisation easier in patients on mitotane

Almazrouei Raya , Meeran Karim , Wernig Florian

Case history: A 66 year old lady presented with abdominal pain, new onset diabetes and hypertension. She was diagnosed with Cushing’s syndrome and was found to have a large heterogeneous left adrenal mass of 11.4 × 9.3 cm in size with no disease elsewhere. She underwent a left open adrenalectomy and the histology confirmed an adrenocortical carcinoma (Weiss score of 7) with focal vascular invasion, no extra-capsular spread and clear resection margins. Following surge...

ea0077p151 | Adrenal and Cardiovascular | SFEBES2021

Iatrogenic Cushing’s syndrome due to betamethasone nasal drops

Alameri Majid , Alnuaimi Abdulla , Patel Kalpesh , Meeran Karim , Wernig Florian

Introduction: Iatrogenic Cushing’s syndrome (ICS) can be caused by virtually all forms of steroid treatment with or without suppression of hypothalamic–pituitary–adrenal (HPA) axis. Here we report betamethasone nasal drops used as treatment post septorhinoplasty as a cause of iatrogenic Cushing’s syndrome.Case: A 36 years old female with background history of depression presented to endocrinology clinic for evaluation of progressive w...

ea0077p226 | Neuroendocrinology and Pituitary | SFEBES2021

Complete third nerve oculomotor nerve palsy as initial presentation of pituitary tuberculosis

Alameri Majid , Alnuaimi Abdulla , Rawson Timothy , Sanderson Frances , Wernig Florian

Introduction: Pituitary tuberculosis (TB) is a rare form of intracranial TB and remains a diagnostic challenge in the absence of systemic TB. A limited number of cases has been reported in the literature.Case: A 47-year-old south Asian man presented to the accident and emergency department with complete isolated left third nerve palsy which had developed gradually over the course of a week. Brain magnetic resonance imagining (MRI) revealed a 15 mm inflam...

ea0052p42 | (1) | UKINETS2017

Therapeutic options in metastatic phaeochromocytomas

Mills Edouard , Dina Roberto , Palazzo Fausto , Sharma Rohini , Wernig Florian

Phaeochromocytomas are rare neuroendocrine tumours. Prediction of aggressive tumour behaviour remains a major challenge. We report a 68-year-old female who was found to have a locally arising colonic adenocarcinoma on biopsies. Staging also identified a 10.7 cm right adrenal lesion and work-up revealed markedly raised urinary metanephrines and positive MIBG imaging. The MDT decision was to first remove the colonic cancer with appropriate alpha blockade. It was felt that a comb...

ea0081ep54 | Adrenal and Cardiovascular Endocrinology | ECE2022

False positive metanephrines secondary to sinemet-diagnostic dilemmas in interpretation

Sharma Bhavna , Qureshi Asjid , Wernig Florian , Seechurn Shivashankar

A 50 year-old lady was referred to the endocrine service for evaluation of significantly elevated 3-methoxytyramine (3-MT) levels. Past medical history included well controlled HIV and hypertension controlled by a single agent only (amlodipine). On one occasion, she was noted to have an elevated systolic blood pressure of 189 mmHg in clinic and therefore 24 h urinary metanephrines were requested. She did not have any other symptoms to suggest excess catecholamines. Systems rev...