Searchable abstracts of presentations at key conferences in endocrinology

ea0059p012 | Adrenal and steroids | SFEBES2018

Newly diagnosed adrenal patients are poorly prepared to manage adrenal crisis

White Katherine

Steroid-dependence is a life-long condition with a risk of premature mortality from undertreated adrenal crisis or omission of steroids. Previous studies identified rates of adrenal crisis around 8.3/100 patient years (Hahner 2015). We invited members of Addison’s Disease Self-Help Group to complete an online questionnaire about any experiences of adrenal crisis. Respondents(N=628) were asked to provide demographic information and details of their most recent adr...

ea0031s3.2 | Nurture not nature: epigenetics and disease susceptibility | SFEBES2013

Nutritional programming of epigenetics in metabolic syndrome

White Anne

There is clear evidence from epidemiological studies that adverse conditions during pregnancy can programme changes in offspring which lead to increased risk of developing type two diabetes and obesity, two diseases associated with metabolic syndrome. Whilst earlier investigations focused on undernutrition in relation to famine, it is also relevant in the developed world to consider how dieting may programme lasting changes in the offspring.In models of ...

ea0021n1.4 | Neuroendocrinology & case presentations | SFEBES2009

Has Carcincioid syndrome given me more than the average number of ears?

White Ian

In 1996, in Monte Carlo’s famous Loewes Hotel, I went from sudden crippling gastric pain to continuous flushing in the space of <24 h, on my return to the UK, I was diagnosed with Carcinoid syndrome. Based on freely available information on the Web at that time, in my mind my life expectancy was going to be 6 years from the point of diagnosis.This session will discuss the impact of a ‘skewed’ sample on the following 6 years of my life ...

ea0021sb1.2 | How to access funds and revolutionise your research | SFEBES2009

Integration of live cell imaging and mathematical modelling: how to use systems biology to revolutionise your research

White M

The advent of high throughput techniques and genome sequencing has brought about a new era in the availability of biological data. This has created a need for new approached for data integration and to interpret complex biological data sets. A cell cannot be considered as using a set of independent signalling pathways. Instead, it is now clear that signalling proteins are integrated into a complex network. The human brain cannot handle this complexity. At the same time, we nee...

ea0013s69 | A successful research career | SFEBES2007

Managing your PhD

White Anne

The decision to undertake a PhD launches you on a path of discovery, but not necessarily scientific discovery!You discover a lot about yourself. Can you survive the failed experiments, the confusion about your goals and the uncertainty about a future career?You discover a lot about working in research groups. Sometimes there is stress with your supervisor, sometimes with other members of the team.The problem ...

ea0050p012 | Adrenal and Steroids | SFEBES2017

It’s a matter of time: the emergence of autoimmune polyendocrine syndrome in autoimmune Addison’s disease reaches 100% among those diagnosed more than 50 years ago

White Katherine , Mackay Alick

Addison’s disease (AD) has an estimated prevalence of 126–144 per million among Northern European populations. Average age at diagnosis is 39, but AD may be diagnosed from pre-teens to 80 year olds.AD may occur in isolation or as part of autoimmune polyendocrine syndromes. Previous studies identified significant associations with autoimmune thyroid disease (predominantly hypothyroidism), type 1 diabetes mellitis, vitiligo, vitamin B12 deficienc...

ea0050p012 | Adrenal and Steroids | SFEBES2017

It’s a matter of time: the emergence of autoimmune polyendocrine syndrome in autoimmune Addison’s disease reaches 100% among those diagnosed more than 50 years ago

White Katherine , Mackay Alick

Addison’s disease (AD) has an estimated prevalence of 126–144 per million among Northern European populations. Average age at diagnosis is 39, but AD may be diagnosed from pre-teens to 80 year olds.AD may occur in isolation or as part of autoimmune polyendocrine syndromes. Previous studies identified significant associations with autoimmune thyroid disease (predominantly hypothyroidism), type 1 diabetes mellitis, vitiligo, vitamin B12 deficienc...

ea0044p14 | Adrenal and Steroids | SFEBES2016

Lowered replacement glucocorticoid doses are associated with a rise in frequency of adrenal crisis

White Katherine , Mackay Alick

Good clinical practice encourages patients to minimise long-term glucocorticoid overexposure to preserve bone density and prevent the development of glucose intolerance or hyperlipidaemia. However, the absence of a protective “cushion” of excess cortisol implies an increased risk of adrenal crisis. (White & Arlt 2010) This assumption has been challenged by a leading adrenal specialist, who suggested instead that chronic over-replacement may increase the susceptib...

ea0038p416 | Steroids | SFEBES2015

Steroid-dependent patients with multiple co-morbidities are more vulnerable to adrenal crisis

White Katherine , Wass John

Steroid-dependent patients have a lifelong dependency on replacement therapy and a lifelong vulnerability to sudden death from under treated adrenal crisis. Yet evidence about the adequacy of medical response to adrenal crisis within the UK is largely anecdotal.We invited members of the main UK support groups representing steroid-dependent patients to complete an online questionnaire identifying the frequency, causes and location of their adrenal crises ...

ea0038p417 | Steroids | SFEBES2015

Comorbidities are the norm for steroid-dependent patients and predispose to adrenal crisis

White Katherine , Wass John

Steroid-dependence is a life-long condition with a risk of premature mortality from undertreated adrenal crisis, hospital omission of steroids, or running out of maintenance drugs at home. We invited members of the main UK support groups representing steroid-dependent patients to complete an online questionnaire about their experiences of adrenal crisis. Respondents (n=1042) were asked to provide demographic information that explored predisposing factors, including co...